Kcna1 - potassium voltage-gated channel subfamily A member 1 Gene

Also Known as Kcna; Kcpvd; Kv1.1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24520

Summary

Enables delayed rectifier Potassium Channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including neuronal action potential; neuronal signal transduction; and positive regulation of voltage-gated Potassium Channel activity. Located in several cellular components, including apical plasma membrane; main axon; and presynaptic membrane. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is active in calyx of Held and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study episodic ataxia type 1 and visual epilepsy. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcna1 Products (1)

mRNA Protein Name
NM_173095.3 NP_775118.1 potassium voltage-gated channel subfamily A member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
8038169 RGD
enables delayed rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
14602579 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7477295 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
8126562 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
8126562 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
8126562 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
8126562 RGD
enables voltage-gated potassium channel activity IMP
IMP: Inferred from mutant phenotype
2555158 RGD
Biological Process GO Annotation Evidence References Source
involved in axon development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in cell communication by electrical coupling IMP
IMP: Inferred from mutant phenotype
22206926 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in corpus callosum development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in membrane repolarization during action potential IDA
IDA: Inferred from direct assay
8038169 RGD
involved in neuronal action potential IMP
IMP: Inferred from mutant phenotype
12177193 RGD
involved in neuronal signal transduction IMP
IMP: Inferred from mutant phenotype
22206926 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in positive regulation of voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
21943416 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
8038169 RGD
involved in potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
2555158 RGD
involved in protein localization IDA
IDA: Inferred from direct assay
10896669 RGD
involved in regulation of muscle contraction IMP
IMP: Inferred from mutant phenotype
22206926 RGD
involved in startle response IMP
IMP: Inferred from mutant phenotype
22206926 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
14602579 RGD
is active in calyx of Held IDA
IDA: Inferred from direct assay
14614103 RGD
located in cell surface IDA
IDA: Inferred from direct assay
22206926 RGD
located in cytosol IDA
IDA: Inferred from direct assay
8038169 RGD
located in dendrite IDA
IDA: Inferred from direct assay
19166515 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10896669 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
14614103 RGD
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
11086297 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10896669 RGD
located in paranode region of axon IDA
IDA: Inferred from direct assay
11086297 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
8038169 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
2555158 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
14614103 RGD
part of potassium channel complex IDA
IDA: Inferred from direct assay
9334400 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
14614103 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
17869444 RGD
part of voltage-gated potassium channel complex IMP
IMP: Inferred from mutant phenotype
12177193 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily A member 1

  • IA

  • RBKI

  • RCK1

  • potassium (K+) channel protein voltage dependent

  • potassium channel, voltage gated shaker related subfamily A, member 1

  • potassium voltage gated channel shaker related subfamily member 1

  • voltage-gated potassium channel subunit Kv1.1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07097 KCNA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcna1 NCBI NCBI:3736