Kcna1 - potassium voltage-gated channel subfamily A member 1 Gene

Rattus norvegicus

Also known as Kcna; Kcpvd; Kv1.1

Gene ID: 24520 | Gene type: protein coding

About Kcna1

Summary

Enables delayed rectifier Potassium Channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including neuronal action potential; neuronal signal transduction; and positive regulation of voltage-gated Potassium Channel activity. Located in several cellular components, including apical plasma membrane; main axon; and presynaptic membrane. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is active in calyx of Held and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study episodic ataxia type 1 and visual epilepsy. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcna1 Products(1)

mRNA	Protein	Name
NM_173095.3	NP_775118.1	potassium voltage-gated channel subfamily A member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	8038169	RGD
enables delayed rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	14602579	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7477295	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	8126562	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	8126562	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	8126562	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	8126562	RGD
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	2555158	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in cell communication by electrical coupling	IMP IMP: Inferred from mutant phenotype	22206926	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in corpus callosum development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in membrane repolarization during action potential	IDA IDA: Inferred from direct assay	8038169	RGD
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	12177193	RGD
involved in neuronal signal transduction	IMP IMP: Inferred from mutant phenotype	22206926	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in positive regulation of voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	21943416	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	8038169	RGD
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	2555158	RGD
involved in protein localization	IDA IDA: Inferred from direct assay	10896669	RGD
involved in regulation of muscle contraction	IMP IMP: Inferred from mutant phenotype	22206926	RGD
involved in startle response	IMP IMP: Inferred from mutant phenotype	22206926	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14602579	RGD
is active in calyx of Held	IDA IDA: Inferred from direct assay	14614103	RGD
located in cell surface	IDA IDA: Inferred from direct assay	22206926	RGD
located in cytosol	IDA IDA: Inferred from direct assay	8038169	RGD
located in dendrite	IDA IDA: Inferred from direct assay	19166515	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10896669	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14614103	RGD
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	11086297	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10896669	RGD
located in paranode region of axon	IDA IDA: Inferred from direct assay	11086297	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	8038169	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	2555158	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	14614103	RGD
part of potassium channel complex	IDA IDA: Inferred from direct assay	9334400	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14614103	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	17869444	RGD
part of voltage-gated potassium channel complex	IMP IMP: Inferred from mutant phenotype	12177193	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily A member 1

IA	RBKI
RCK1	potassium (K+) channel protein voltage dependent
potassium channel, voltage gated shaker related subfamily A, member 1	potassium voltage gated channel shaker related subfamily member 1
voltage-gated potassium channel subunit Kv1.1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07097	KCNA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcna1	NCBI	NCBI:3736

Name
Email *

	Sorry, but the email address you supplied was invalid.