SPDYA - speedy/RINGO cell cycle regulator family member A Gene

Also Known as SPY1; SPDY1; RINGO3; RINGOA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 245711

About SPDYA

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,810,834-28,850,610 (from NCBI)

This gene has 7 transcripts (splice variants), 188 orthologues and 1 paralogue. Biased expression in testis (RPKM 22.5), duodenum (RPKM 1.7) and 10 other tissues.

Summary

Enables protein kinase activator activity and protein kinase binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SPDYA Products (3)

mRNA Protein Name
NM_001008779.1 NP_001008779.1 speedy protein A isoform 2
NM_001142634.2 NP_001136106.1 speedy protein A isoform 1
NM_182756.4 NP_877433.2 speedy protein A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein kinase activator activity IDA
IDA: Inferred from direct assay
28666995 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11980914 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
12839962 GOA
involved in G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
11980914 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11980914 GOA
involved in positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
28666995 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11980914 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPDYA Protein Structure

Spy1

Spy1: Cell cycle regulatory protein (69 - 199)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

speedy protein A

  • RINGO A

Related Diseases

Diseases Alias
Hypertrophy Of Breast

  • Breasts Enlarged

  • Large Breast

  • Hypertrophy Of Breast Nos

  • Hypertrophy Of Male Breast

  • Hypertrophic Breast

  • Excessive Development Of Breast

  • Macromastia

  • Mastoplastia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13654 SPDYA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SPDYA VGNC VGNC:46728
Mus musculus SPDYA MGD MGI:1918141
Bos taurus SPDYA VGNC VGNC:54492
Macaca mulatta SPDYA VGNC VGNC:106224
Felis catus SPDYA VGNC VGNC:65629
Rattus norvegicus SPDYA RGD RGD:621730
Others SPDYA NCBI