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Vps54 - VPS54 GARP complex subunit Gene

Also Known as wr; Hcc8; mSLP8; Vps54l

Species: Mus musculus

Gene Type: protein coding

Gene ID: 245944

Summary

Predicted to enable syntaxin binding activity. Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; musculoskeletal movement; and neurofilament Cytoskeleton organization. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and trans-Golgi network. Predicted to be part of GARP complex. Used to study Werdnig-Hoffmann disease and amyotrophic lateral sclerosis type 1. Orthologous to human VPS54 (VPS54 subunit of GARP complex). [provided by Alliance of Genome Resources, Apr 2022]

Vps54 Products (2)

mRNA	Protein	Name
NM_001290628.1	NP_001277557.1	vacuolar protein sorting-associated protein 54 isoform 2
NM_139061.5	NP_620692.3	vacuolar protein sorting-associated protein 54 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in L-glutamate import	IMP IMP: Inferred from mutant phenotype	20558160	MGI
involved in apoptotic DNA fragmentation	IMP IMP: Inferred from mutant phenotype	11403940	MGI
involved in astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	29890290	MGI
involved in cellular response to progesterone stimulus	IMP IMP: Inferred from mutant phenotype	22486171	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	10739637	MGI
involved in homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	24141020	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	8815872	MGI
involved in homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	24349357	MGI
involved in in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16244655	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	23872513	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	24141020	MGI
involved in limb morphogenesis	IMP IMP: Inferred from mutant phenotype	24141020	MGI
involved in microglia differentiation	IMP IMP: Inferred from mutant phenotype	29890290	MGI
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	22486171	MGI
involved in motor behavior	IMP IMP: Inferred from mutant phenotype	29890290	MGI
involved in motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10952021	MGI
acts upstream of or within musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	8815872	MGI
involved in negative regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16244655	MGI
involved in neural tissue regeneration	IMP IMP: Inferred from mutant phenotype	24141020	MGI
acts upstream of or within neurofilament cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11493023	MGI
involved in neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	29890290	MGI
involved in neuromuscular synaptic transmission	IMP IMP: Inferred from mutant phenotype	24349357	MGI
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20558160	MGI
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	20558160	MGI
involved in post-embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	11403940	MGI
involved in protein localization	IMP IMP: Inferred from mutant phenotype	19013502	MGI
involved in protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	23708095	MGI
involved in protein targeting to ER	IMP IMP: Inferred from mutant phenotype	28658628	MGI
involved in protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	28658628	MGI
involved in protein targeting to vacuole	IMP IMP: Inferred from mutant phenotype	23708095	MGI
acts upstream of or within regulation of growth	IMP IMP: Inferred from mutant phenotype	8815872	MGI
involved in respiratory electron transport chain	IMP IMP: Inferred from mutant phenotype	22486171	MGI
involved in response to antibiotic	IMP IMP: Inferred from mutant phenotype	32345721	MGI
involved in response to calcium ion	IMP IMP: Inferred from mutant phenotype	10739637	MGI
involved in skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	11403940	MGI
involved in skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	23872513	MGI
involved in spermatid differentiation	IMP IMP: Inferred from mutant phenotype	16244655	MGI
involved in sphingolipid catabolic process	IMP IMP: Inferred from mutant phenotype	32345721	MGI
involved in striated muscle contraction	IMP IMP: Inferred from mutant phenotype	10739637	MGI
involved in synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	20643756	MGI
involved in synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	29890290	MGI
involved in thrombin-activated receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10952021	MGI
involved in ubiquitin recycling	IMP IMP: Inferred from mutant phenotype	19013502	MGI
involved in vacuole organization	IMP IMP: Inferred from mutant phenotype	11403940	MGI
involved in vesicle-mediated cholesterol transport	IMP IMP: Inferred from mutant phenotype	28658628	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of GARP complex	IDA IDA: Inferred from direct assay	20615984	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	19013502	MGI
is active in mitochondrion	IMP IMP: Inferred from mutant phenotype	22486171	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 54	tumor antigen SLP-8p homolog vacuolar protein sorting 54

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15699	VPS54 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vps54	NCBI	NCBI:51542