Kcne2 - potassium voltage-gated channel, Isk-related subfamily, gene 2 Gene

Also Known as MiRP1; 2200002I16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 246133

Summary

Predicted to enable several functions, including identical protein binding activity; transmembrane transporter binding activity; and voltage-gated Potassium Channel activity. Predicted to contribute to delayed rectifier Potassium Channel activity; inward rectifier Potassium Channel activity; and voltage-gated Potassium Channel activity involved in ventricular cardiac muscle cell action potential repolarization. Involved in iodide transport; multicellular organismal response to stress; and myo-inositol transport. Acts upstream of or within several processes, including potassium ion transmembrane transport; regulation of ventricular cardiac muscle cell membrane repolarization; and ventricular cardiac muscle cell action potential. Located in membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in atrial fibrillation; familial atrial fibrillation; long QT syndrome; and long QT syndrome 6. Orthologous to human KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcne2 Products (2)

mRNA Protein Name
NM_001358372.1 NP_001345301.1 potassium voltage-gated channel subfamily E member 2
NM_134110.3 NP_598871.1 potassium voltage-gated channel subfamily E member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18603586 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
18603586 MGI
involved in iodide transport IMP
IMP: Inferred from mutant phenotype
22549510 MGI
involved in multicellular organismal response to stress IMP
IMP: Inferred from mutant phenotype
24595108 MGI
involved in myo-inositol transport IMP
IMP: Inferred from mutant phenotype
24595108 MGI
acts upstream of or within potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
18603586 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
18603586 MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane repolarization IMP
IMP: Inferred from mutant phenotype
18603586 MGI
acts upstream of or within ventricular cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
18603586 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
24595108 MGI
located in membrane IDA
IDA: Inferred from direct assay
18603586 MGI
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
24595108 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily E member 2

  • minK-related peptide 1

  • minimum potassium ion channel related peptide 1

  • potassium channel subunit beta MiRP1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07116 KCNE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121977 IKs124 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcne2 NCBI NCBI:9992