Kcne2 - potassium voltage-gated channel, Isk-related subfamily, gene 2 Gene

Mus musculus

Also known as MiRP1; 2200002I16Rik

Gene ID: 246133 | Gene type: protein coding

About Kcne2

Summary

Predicted to enable several functions, including identical protein binding activity; transmembrane transporter binding activity; and voltage-gated Potassium Channel activity. Predicted to contribute to delayed rectifier Potassium Channel activity; inward rectifier Potassium Channel activity; and voltage-gated Potassium Channel activity involved in ventricular cardiac muscle cell action potential repolarization. Involved in iodide transport; multicellular organismal response to stress; and myo-inositol transport. Acts upstream of or within several processes, including potassium ion transmembrane transport; regulation of ventricular cardiac muscle cell membrane repolarization; and ventricular cardiac muscle cell action potential. Located in membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in atrial fibrillation; familial atrial fibrillation; long QT syndrome; and long QT syndrome 6. Orthologous to human KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcne2 Products(2)

mRNA	Protein	Name
NM_001358372.1	NP_001345301.1	potassium voltage-gated channel subfamily E member 2
NM_134110.3	NP_598871.1	potassium voltage-gated channel subfamily E member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18603586	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	18603586	MGI
involved in iodide transport	IMP IMP: Inferred from mutant phenotype	22549510	MGI
involved in multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	24595108	MGI
involved in myo-inositol transport	IMP IMP: Inferred from mutant phenotype	24595108	MGI
acts upstream of or within potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	18603586	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	18603586	MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	18603586	MGI
acts upstream of or within ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	18603586	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	24595108	MGI
located in membrane	IDA IDA: Inferred from direct assay	18603586	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	24595108	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily E member 2

minK-related peptide 1	minimum potassium ion channel related peptide 1
potassium channel subunit beta MiRP1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07116	KCNE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121977	IKs124	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcne2	NCBI	NCBI:9992

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