Kcnc2 - potassium voltage-gated channel subfamily C member 2 Gene

Rattus norvegicus

Also known as Kv3.2; KShIIIA

Gene ID: 246153 | Gene type: protein coding

About Kcnc2

Summary

Enables delayed rectifier Potassium Channel activity; transmembrane transporter binding activity; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including cellular response to nitric oxide; globus pallidus development; and protein complex oligomerization. Located in several cellular components, including axon; basolateral plasma membrane; and neuronal cell body membrane. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnc2 Products(2)

mRNA	Protein	Name
NM_139216.1	NP_631962.1	potassium voltage-gated channel subfamily C member 2 isoform a
NM_139217.1	NP_631963.1	potassium voltage-gated channel subfamily C member 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	1879548	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12805291	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	10482766	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	10482766	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	10482766	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	7643197	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ammonium ion	IEP IEP: Inferred from expression pattern	10482766	RGD
involved in cellular response to nitric oxide	IDA IDA: Inferred from direct assay	11281123	RGD
involved in cellular response to toxic substance	IEP IEP: Inferred from expression pattern	17855760	RGD
involved in cellular response to toxic substance	IMP IMP: Inferred from mutant phenotype	16177043	RGD
involved in globus pallidus development	IEP IEP: Inferred from expression pattern	10482766	RGD
involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	17855760	RGD
involved in nitric oxide-cGMP-mediated signaling	IDA IDA: Inferred from direct assay	11281123	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in positive regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	1879548	RGD
involved in positive regulation of voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	21943417	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	7643197	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	1879548	RGD
involved in protein heterooligomerization	IDA IDA: Inferred from direct assay	10482766	RGD
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	10482766	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	18775767	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	21234782	RGD
involved in response to light intensity	IEP IEP: Inferred from expression pattern	18708127	RGD
involved in response to magnesium ion	IEP IEP: Inferred from expression pattern	18775767	RGD
involved in response to nerve growth factor	IEP IEP: Inferred from expression pattern	18775767	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	7643197	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	18775767	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	10531438	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	9307441	RGD
located in axolemma	IDA IDA: Inferred from direct assay	15488478	RGD
located in axon	IDA IDA: Inferred from direct assay	7643197	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9307441	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16413129	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16413129	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	7643197	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	10482766	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	11281123	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	10531438	RGD
located in synapse	IDA IDA: Inferred from direct assay	7643197	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15488478	RGD
located in vesicle	IDA IDA: Inferred from direct assay	15488478	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	10482766	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily C member 2

potassium channel voltage-gated Shaw-related subfamily C member 2	potassium voltage gated channel, Shaw-related subfamily, member 2
shaw-like potassium channel	voltage-gated potassium channel subunit Kv3.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07109	KCNC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnc2	NCBI	NCBI:3747

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