Kcnc2 - potassium voltage-gated channel subfamily C member 2 Gene

Also Known as Kv3.2; KShIIIA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246153

Summary

Enables delayed rectifier Potassium Channel activity; transmembrane transporter binding activity; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including cellular response to nitric oxide; globus pallidus development; and protein complex oligomerization. Located in several cellular components, including axon; basolateral plasma membrane; and neuronal cell body membrane. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnc2 Products (2)

mRNA Protein Name
NM_139216.1 NP_631962.1 potassium voltage-gated channel subfamily C member 2 isoform a
NM_139217.1 NP_631963.1 potassium voltage-gated channel subfamily C member 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
1879548 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12805291 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
10482766 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
10482766 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
10482766 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
7643197 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to ammonium ion IEP
IEP: Inferred from expression pattern
10482766 RGD
involved in cellular response to nitric oxide IDA
IDA: Inferred from direct assay
11281123 RGD
involved in cellular response to toxic substance IEP
IEP: Inferred from expression pattern
17855760 RGD
involved in cellular response to toxic substance IMP
IMP: Inferred from mutant phenotype
16177043 RGD
involved in globus pallidus development IEP
IEP: Inferred from expression pattern
10482766 RGD
involved in monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
17855760 RGD
involved in nitric oxide-cGMP-mediated signaling IDA
IDA: Inferred from direct assay
11281123 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in positive regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
1879548 RGD
involved in positive regulation of voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
21943417 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
7643197 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
1879548 RGD
involved in protein heterooligomerization IDA
IDA: Inferred from direct assay
10482766 RGD
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
10482766 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
18775767 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
21234782 RGD
involved in response to light intensity IEP
IEP: Inferred from expression pattern
18708127 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
18775767 RGD
involved in response to nerve growth factor IEP
IEP: Inferred from expression pattern
18775767 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
7643197 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
18775767 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
10531438 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
9307441 RGD
located in axolemma IDA
IDA: Inferred from direct assay
15488478 RGD
located in axon IDA
IDA: Inferred from direct assay
7643197 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
9307441 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16413129 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16413129 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
7643197 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
10482766 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11281123 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
10531438 RGD
located in synapse IDA
IDA: Inferred from direct assay
7643197 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
15488478 RGD
located in vesicle IDA
IDA: Inferred from direct assay
15488478 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
10482766 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily C member 2

  • potassium channel voltage-gated Shaw-related subfamily C member 2

  • potassium voltage gated channel, Shaw-related subfamily, member 2

  • shaw-like potassium channel

  • voltage-gated potassium channel subunit Kv3.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07109 KCNC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnc2 NCBI NCBI:3747