Hsd3b7 - hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Gene

Also Known as Cca2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246211

Summary

Enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity. Involved in Cholesterol catabolic process; liver regeneration; and regulation of cell growth. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 1 and intrahepatic cholestasis. Orthologous to human HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7). [provided by Alliance of Genome Resources, Apr 2022]

Hsd3b7 Products (2)

mRNA Protein Name
NM_001398675.1 NP_001385604.1 3 beta-hydroxysteroid dehydrogenase type 7 isoform 1
NM_139329.3 NP_647545.2 3 beta-hydroxysteroid dehydrogenase type 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity IDA
IDA: Inferred from direct assay
16081591 RGD
Biological Process GO Annotation Evidence References Source
involved in cholesterol catabolic process IDA
IDA: Inferred from direct assay
16081591 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
16081591 RGD
involved in regulation of cell growth IDA
IDA: Inferred from direct assay
9199244 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3 beta-hydroxysteroid dehydrogenase type 7

  • 3 beta-hydroxysteroid dehydrogenase type VII

  • 3-beta-HSD VII

  • 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase

  • c(27) 3-beta-HSD

  • cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase

  • confluent 3Y1 cell-associated 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06403 HSD3B7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd3b7 NCBI NCBI:80270