Sipa1l1 - signal-induced proliferation-associated 1 like 1 Gene

Also Known as SPAL; Spa1; Spar; Spa-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 246212

Summary

Enables actin filament binding activity; protein kinase binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including actin Cytoskeleton organization; activation of GTPase activity; and regulation of postsynapse organization. Located in dendritic spine; neuronal cell body; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Sipa1l1 Products (2)

mRNA	Protein	Name
NM_001389245.1	NP_001376174.1	signal-induced proliferation-associated 1-like protein 1 isoform 2
NM_139330.2	NP_647546.2	signal-induced proliferation-associated 1-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	11502259	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11502259	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18498738	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	18723513	RGD
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	18723513	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11502259	RGD
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	11502259	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11502259	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11502259	RGD
involved in regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	15703396	RGD
involved in regulation of dendritic spine morphogenesis	IDA IDA: Inferred from direct assay	11502259	RGD
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	11502259	RGD
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	11502259	RGD
involved in regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	21382555	RGD
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	15703396	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	11502259	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11502259	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11502259	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12059963	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	11502259	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	11502259	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15823548	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
signal-induced proliferation-associated 1-like protein 1	SIPA1-like protein 1 SPA-1 like protein SPA-1-like protein p1294 spine-associated Rap GTPase-activating protein spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12929	SIPA1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sipa1l1	NCBI	NCBI:26037