Myocd - myocardin Gene

Rattus norvegicus

Also known as Mycd

Gene ID: 246297 | Gene type: protein coding

About Myocd

Summary

Predicted to enable several functions, including R-SMAD binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including hepatic stellate cell activation; positive regulation of cell differentiation; and positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in congenital megabladder. Orthologous to human MYOCD (myocardin). [provided by Alliance of Genome Resources, Apr 2022]

Myocd Products(2)

mRNA	Protein	Name
NM_001414232.1	NP_001401161.1	myocardin isoform 1
NM_182667.3	NP_872608.1	myocardin isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16054032	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac vascular smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	16151017	RGD
involved in cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	18772130	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	15016729	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	20621093	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20621093	RGD
involved in hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	19793196	RGD
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	23270756	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12392995	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19237536	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	23855625	RGD
involved in regulation of smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	12756293	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	23855625	RGD
involved in response to muscle stretch	IEP IEP: Inferred from expression pattern	23855625	RGD
involved in smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	12392995	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19237536	RGD
located in nucleus	IDA IDA: Inferred from direct assay	19237536	RGD
part of protein-DNA complex	IDA IDA: Inferred from direct assay	15016729	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myocardin

transcription factor myocardin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08955	MYOCD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myocd	NCBI	NCBI:93649

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