Abcb1b - ATP-binding cassette, subfamily B (MDR/TAP), member 1B Gene

Also Known as Mdr1; Pgy1; Abcb1; mdr1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24646

Summary

Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including Sertoli cell barrier remodeling; animal organ development; and cellular response to external biotic stimulus. Located in Golgi membrane and external side of apical plasma membrane. Used to study brain disease (multiple); colorectal adenocarcinoma; end stage renal disease; and human immunodeficiency virus infectious disease. Biomarker of brain disease (multiple); cholestasis; human immunodeficiency virus infectious disease; non-alcoholic fatty liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Abcb1b Products (2)

mRNA Protein Name
NM_012623.3 NP_036755.3 ATP-dependent translocase ABCB1
NM_012623.3 NP_036755.3 ATP-dependent translocase ABCB1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15159385 RGD
Biological Process GO Annotation Evidence References Source
involved in Sertoli cell barrier remodeling IMP
IMP: Inferred from mutant phenotype
28880272 RGD
involved in cellular response to external biotic stimulus IEP
IEP: Inferred from expression pattern
16353156 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
19088456 RGD
involved in establishment of endothelial blood-brain barrier IMP
IMP: Inferred from mutant phenotype
16850390 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
19702690 RGD
involved in placenta development IEP
IEP: Inferred from expression pattern
15279876 RGD
involved in response to antineoplastic agent IEP
IEP: Inferred from expression pattern
12154027 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
16436460 RGD
involved in response to genistein IEP
IEP: Inferred from expression pattern
26316063 RGD
involved in response to glycoside IEP
IEP: Inferred from expression pattern
21590773 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
19323616 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
16494520 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17285300 RGD
involved in response to mycotoxin IEP
IEP: Inferred from expression pattern
23707492 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19549930 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
16483613 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
26729079 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
14622113 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
10748167 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10748167 RGD
located in external side of apical plasma membrane IDA
IDA: Inferred from direct assay
18619525 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent translocase ABCB1

  • ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)

  • ATP-binding cassette sub-family B member 1

  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)

  • ATP-binding cassette,

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00048 ABCB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00049 ABCB10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00050 ABCB11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21085 Abcb10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27603 Abcb10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown