2. Gene
  3. Pmp22 - peripheral myelin protein 22 Gene

Pmp22 - peripheral myelin protein 22 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gas-3

Gene ID: 24660 | Gene type: protein coding

About Pmp22

Summary

Predicted to enable cytoskeletal motor activity. Involved in several processes, including myelination; negative regulation of cell population proliferation; and negative regulation of neuron projection development. Located in bicellular tight junction and compact myelin. Is integral component of membrane. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); Guillain-Barre syndrome; and hereditary neuropathy with liability to pressure palsies. Orthologous to human PMP22 (peripheral myelin protein 22). [provided by Alliance of Genome Resources, Apr 2022]

Pmp22 Products(1)

mRNA Protein Name
NM_017037.2 NP_058733.2 peripheral myelin protein 22
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cell differentiation IDA
IDA: Inferred from direct assay
11456309 RGD
involved in myelination IDA
IDA: Inferred from direct assay
11456309 RGD
involved in myelination IMP
IMP: Inferred from mutant phenotype
11456309 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11519720 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
7720703 RGD
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
11519720 RGD
Cellular Component GO Annotation Evidence Reference Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
11717414 RGD
located in compact myelin IDA
IDA: Inferred from direct assay
1556154 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peripheral myelin protein 22

PMP-22

SAG

SR13 myelin protein

schwann cell membrane glycoprotein

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-179114 VU0519975 / Unkown
HY-RS10769 PMP22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11482 PXMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22756 Pxmp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pmp22 NCBI NCBI:5376