Scnn1g - sodium channel epithelial 1 subunit gamma Gene

Rattus norvegicus

Also known as ENaC

Gene ID: 24768 | Gene type: protein coding

About Scnn1g

Summary

Enables WW domain binding activity and ligand-gated Sodium Channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in response to hypoxia; sodium ion transport; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and cell surface. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1G (Sodium Channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Scnn1g Products(1)

mRNA	Protein	Name
NM_017046.2	NP_058742.2	amiloride-sensitive sodium channel subunit gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	8665844	RGD
enables ligand-gated sodium channel activity	IDA IDA: Inferred from direct assay	16356937	RGD
contributes to ligand-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	9118951	RGD
enables ligand-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	11773057	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11527431	RGD
contributes to sodium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	8107805	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	17562820	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	12372821	RGD
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	17562820	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	16554417	RGD
involved in sodium ion transport	IMP IMP: Inferred from mutant phenotype	11773057	RGD
involved in wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	16844921	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	9118951	RGD
located in cell surface	IDA IDA: Inferred from direct assay	16476738	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amiloride-sensitive sodium channel subunit gamma

SCNEG	Sodium channel, nonvoltage-gated 1, gamma (epithelial)
amiloride sensitive sodium channel gamma1 subunit	epithelial Na(+) channel subunit gamma
epithelial sodium channel gamma subunit	gamma-ENaC
gamma-NaCH	nonvoltage-gated sodium channel 1 su

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12555	SCNN1G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scnn1g	NCBI	NCBI:6340

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