Scnn1g - sodium channel epithelial 1 subunit gamma Gene

Also Known as ENaC

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24768

Summary

Enables WW domain binding activity and ligand-gated Sodium Channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in response to hypoxia; sodium ion transport; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and cell surface. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1G (Sodium Channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Scnn1g Products (1)

mRNA Protein Name
NM_017046.2 NP_058742.2 amiloride-sensitive sodium channel subunit gamma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
8665844 RGD
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
16356937 RGD
contributes to ligand-gated sodium channel activity IMP
IMP: Inferred from mutant phenotype
9118951 RGD
enables ligand-gated sodium channel activity IMP
IMP: Inferred from mutant phenotype
11773057 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11527431 RGD
contributes to sodium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
8107805 RGD
Biological Process GO Annotation Evidence References Source
involved in intracellular sodium ion homeostasis IDA
IDA: Inferred from direct assay
17562820 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
12372821 RGD
involved in sodium ion import across plasma membrane IDA
IDA: Inferred from direct assay
17562820 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
16554417 RGD
involved in sodium ion transport IMP
IMP: Inferred from mutant phenotype
11773057 RGD
involved in wound healing, spreading of epidermal cells IMP
IMP: Inferred from mutant phenotype
16844921 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
9118951 RGD
located in cell surface IDA
IDA: Inferred from direct assay
16476738 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amiloride-sensitive sodium channel subunit gamma

  • SCNEG

  • Sodium channel, nonvoltage-gated 1, gamma (epithelial)

  • amiloride sensitive sodium channel gamma1 subunit

  • epithelial Na(+) channel subunit gamma

  • epithelial sodium channel gamma subunit

  • gamma-ENaC

  • gamma-NaCH

  • nonvoltage-gated sodium channel 1 su

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12555 SCNN1G Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scnn1g NCBI NCBI:6340