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Tacr1 - tachykinin receptor 1 Gene

Also Known as Tac1r

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24807

About Tacr1

Primary_assembly 4: 114,920,844-115,089,733 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 270 orthologues, 50 paralogues and is associated with 34 phenotypes. Biased expression in Spleen (RPKM 7.7), Brain (RPKM 7.5) and 8 other tissues.

Summary

Enables substance P receptor activity. Involved in several processes, including learning or memory; positive regulation of secretion; and regulation of cell migration. Located in several cellular components, including cell body; cell surface; and dendrite. Used to study central sleep apnea; cystitis; pancreatitis; and pulmonary hypertension. Biomarker of acute necrotizing pancreatitis; allergic rhinitis; asthma; colitis; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in exercise-induced bronchoconstriction. Orthologous to human TACR1 (tachykinin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tacr1 Products (1)

mRNA	Protein	Name
NM_012667.3	NP_036799.1	substance-P receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables substance P receptor activity	IDA IDA: Inferred from direct assay	7683643	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in aggressive behavior	IMP IMP: Inferred from mutant phenotype	17678879	RGD
involved in angiotensin-mediated drinking behavior	IMP IMP: Inferred from mutant phenotype	9437747	RGD
involved in associative learning	IMP IMP: Inferred from mutant phenotype	19071162	RGD
involved in behavioral response to pain	IMP IMP: Inferred from mutant phenotype	18407414	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	17141213	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	21611833	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	19071162	RGD
involved in operant conditioning	IMP IMP: Inferred from mutant phenotype	17324063	RGD
involved in positive regulation of action potential	IMP IMP: Inferred from mutant phenotype	18440151	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18337316	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	17435548	RGD
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	17435548	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18390473	RGD
involved in positive regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	15613740	RGD
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	11803123	RGD
involved in positive regulation of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	18621988	RGD
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	17204323	RGD
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	17435548	RGD
involved in positive regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	19261870	RGD
involved in positive regulation of synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	17949415	RGD
involved in positive regulation of uterine smooth muscle contraction	IDA IDA: Inferred from direct assay	12390879	RGD
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	18326823	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	18602450	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18938661	RGD
involved in regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	21777465	RGD
involved in regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21777465	RGD
involved in response to auditory stimulus	IDA IDA: Inferred from direct assay	18178320	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	18440496	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	10342838	RGD
involved in response to ethanol	IMP IMP: Inferred from mutant phenotype	18555214	RGD
involved in response to hormone	IMP IMP: Inferred from mutant phenotype	18195491	RGD
involved in response to nicotine	IMP IMP: Inferred from mutant phenotype	18037142	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	18178320	RGD
involved in response to ozone	IMP IMP: Inferred from mutant phenotype	18390473	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	10342838	RGD
involved in smooth muscle contraction involved in micturition	IMP IMP: Inferred from mutant phenotype	18945947	RGD
involved in sperm ejaculation	IMP IMP: Inferred from mutant phenotype	19170843	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell body	IDA IDA: Inferred from direct assay	21611833	RGD
located in cell surface	IDA IDA: Inferred from direct assay	19261870	RGD
located in dendrite	IDA IDA: Inferred from direct assay	18178320	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	7508118	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tacr1 Protein Structure

7tm_GPCRs

0
100
200
300
407 a.a.

Protein Preferred Names	Protein Names
substance-P receptor	NK-1 receptor NK-1R SPR neurokinin 1 receptor substance p receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14143	TACR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14144	Tacr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14145	Tacr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tacr1	NCBI	NCBI:6869