Add3 - adducin 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25230

Summary

Enables protein kinase C binding activity. Involved in positive regulation of Cytoskeleton organization; positive regulation of vasoconstriction; and response to xenobiotic stimulus. Located in Cytoskeleton. Used to study hypertension and proteinuria. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human ADD3 (adducin 3). [provided by Alliance of Genome Resources, Apr 2022]

Add3 Products (2)

mRNA Protein Name
NM_001164103.1 NP_001157575.1 gamma-adducin isoform 1
NM_031552.2 NP_113740.2 gamma-adducin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7592723 RGD
enables protein kinase C binding IDA
IDA: Inferred from direct assay
8442667 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
32029431 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
27927653 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
10823823 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-adducin

  • adducin 3 (gamma)

  • adducin-like protein 70

  • potein kinase C binding protein 35H

  • protein kinase C-binding protein 35H

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00340 ADD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Add3 NCBI NCBI:120