Add3 - adducin 3 Gene

Rattus norvegicus

Gene ID: 25230 | Gene type: protein coding

About Add3

Summary

Enables protein kinase C binding activity. Involved in positive regulation of Cytoskeleton organization; positive regulation of vasoconstriction; and response to xenobiotic stimulus. Located in Cytoskeleton. Used to study hypertension and proteinuria. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human ADD3 (adducin 3). [provided by Alliance of Genome Resources, Apr 2022]

Add3 Products(2)

mRNA	Protein	Name
NM_001164103.1	NP_001157575.1	gamma-adducin isoform 1
NM_031552.2	NP_113740.2	gamma-adducin isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7592723	RGD
enables protein kinase C binding	IDA IDA: Inferred from direct assay	8442667	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	32029431	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	27927653	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	10823823	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-adducin

adducin 3 (gamma)	adducin-like protein 70
potein kinase C binding protein 35H	protein kinase C-binding protein 35H

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00340	ADD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Add3	NCBI	NCBI:120

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