Slc38a3 - solute carrier family 38, member 3 Gene

Rattus norvegicus

Also known as Sn1; Nat1; Snat3

Gene ID: 252919 | Gene type: protein coding

About Slc38a3

Summary

Enables L-asparagine transmembrane transporter activity; L-glutamine transmembrane transporter activity; and L-histidine transmembrane transporter activity. Involved in several processes, including amino acid transport; female pregnancy; and positive regulation of glutamine transport. Located in basolateral plasma membrane. Is integral component of plasma membrane. Biomarker of metabolic acidosis and visual epilepsy. Orthologous to human SLC38A3 (solute carrier family 38 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc38a3 Products(1)

mRNA	Protein	Name
NM_145776.2	NP_665719.1	sodium-coupled neutral amino acid transporter 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-asparagine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10619430	RGD
enables L-asparagine, sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	11742981	RGD
enables L-glutamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10619430	RGD
enables L-glutamine, sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	11742981	RGD
enables L-histidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10619430	RGD
enables L-histidine, sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	11742981	RGD
enables neutral L-amino acid:sodium symporter activity	IDA IDA: Inferred from direct assay	16249471	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-asparagine import across plasma membrane	IDA IDA: Inferred from direct assay	11742981	RGD
involved in L-glutamine import across plasma membrane	IDA IDA: Inferred from direct assay	11742981	RGD
involved in L-histidine transport	IDA IDA: Inferred from direct assay	11742981	RGD
involved in asparagine transport	IDA IDA: Inferred from direct assay	10619430	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	19892400	RGD
involved in glutamine secretion	IDA IDA: Inferred from direct assay	11850497	RGD
involved in glutamine transport	IDA IDA: Inferred from direct assay	10619430	RGD
involved in histidine transport	IDA IDA: Inferred from direct assay	10619430	RGD
involved in positive regulation of glutamine transport	IDA IDA: Inferred from direct assay	17148440	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15716335	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	10619430	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium-coupled neutral amino acid transporter 3

N-system amino acid transporter 1	Na(+)-coupled neutral amino acid transporter 3
system N amino acid transporter 1	system N1 amino acid transporter

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13221	SLC38A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22043	Slc38a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc38a3	NCBI	NCBI:10991

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