Slc38a3 - solute carrier family 38, member 3 Gene

Also Known as Sn1; Nat1; Snat3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 252919

Summary

Enables L-asparagine transmembrane transporter activity; L-glutamine transmembrane transporter activity; and L-histidine transmembrane transporter activity. Involved in several processes, including amino acid transport; female pregnancy; and positive regulation of glutamine transport. Located in basolateral plasma membrane. Is integral component of plasma membrane. Biomarker of metabolic acidosis and visual epilepsy. Orthologous to human SLC38A3 (solute carrier family 38 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc38a3 Products (1)

mRNA Protein Name
NM_145776.2 NP_665719.1 sodium-coupled neutral amino acid transporter 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-asparagine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10619430 RGD
enables L-asparagine, sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
11742981 RGD
enables L-glutamine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10619430 RGD
enables L-glutamine, sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
11742981 RGD
enables L-histidine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10619430 RGD
enables L-histidine, sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
11742981 RGD
enables neutral L-amino acid:sodium symporter activity IDA
IDA: Inferred from direct assay
16249471 RGD
Biological Process GO Annotation Evidence References Source
involved in L-asparagine import across plasma membrane IDA
IDA: Inferred from direct assay
11742981 RGD
involved in L-glutamine import across plasma membrane IDA
IDA: Inferred from direct assay
11742981 RGD
involved in L-histidine transport IDA
IDA: Inferred from direct assay
11742981 RGD
involved in asparagine transport IDA
IDA: Inferred from direct assay
10619430 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
19892400 RGD
involved in glutamine secretion IDA
IDA: Inferred from direct assay
11850497 RGD
involved in glutamine transport IDA
IDA: Inferred from direct assay
10619430 RGD
involved in histidine transport IDA
IDA: Inferred from direct assay
10619430 RGD
involved in positive regulation of glutamine transport IDA
IDA: Inferred from direct assay
17148440 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15716335 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
10619430 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium-coupled neutral amino acid transporter 3

  • N-system amino acid transporter 1

  • Na(+)-coupled neutral amino acid transporter 3

  • system N amino acid transporter 1

  • system N1 amino acid transporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13221 SLC38A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22043 Slc38a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc38a3 NCBI NCBI:10991