2. Gene
  3. Tpcn1 - two pore channel 1 Gene

Tpcn1 - two pore channel 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tpc1; mKIAA1169; 5730403B01Rik

Gene ID: 252972 | Gene type: protein coding

About Tpcn1

Summary

Enables several functions, including cation channel activity; phosphatidylinositol-3,5-bisphosphate binding activity; and protein homodimerization activity. Involved in endocytosis involved in viral entry into host cell and sodium ion transmembrane transport. Located in early endosome membrane; endolysosome; and recycling endosome membrane. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human TPCN1 (two pore segment channel 1). [provided by Alliance of Genome Resources, Apr 2022]

Tpcn1 Products(1)

mRNA Protein Name
NM_145853.2 NP_665852.1 two pore calcium channel protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT enables NAADP-sensitive calcium-release channel activity IDA
IDA: Inferred from direct assay
24776928 MGI
enables intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity IDA
IDA: Inferred from direct assay
24776928 MGI
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
24776928 MGI
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: Inferred from direct assay
29562233 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
29562233 MGI
enables syntaxin binding IPI
IPI: Inferred from physical interaction
28855648 MGI
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
24776928 MGI
Biological Process GO Annotation Evidence Reference Source
involved in endocytosis involved in viral entry into host cell IMP
IMP: Inferred from mutant phenotype
25722412 MGI
involved in sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
29562233 MGI
Cellular Component GO Annotation Evidence Reference Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
28855648 MGI
located in endolysosome IDA
IDA: Inferred from direct assay
24776928 MGI
located in membrane IDA
IDA: Inferred from direct assay
29562233 MGI
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
28855648 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

two pore calcium channel protein 1

voltage-dependent calcium channel protein TPC1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14926 TPCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpcn1 NCBI NCBI:53373