Kcnc1 - potassium voltage-gated channel subfamily C member 1 Gene

Rattus norvegicus

Also known as Kv4; Kv3.1; KShIIIB; NGK2-KV4

Gene ID: 25327 | Gene type: protein coding

About Kcnc1

Summary

Enables delayed rectifier Potassium Channel activity; transmembrane transporter binding activity; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including brain development; positive regulation of voltage-gated Potassium Channel activity; and response to auditory stimulus. Located in several cellular components, including dendrite; neuron projection membrane; and neuronal cell body membrane. Part of voltage-gated Potassium Channel complex. Is active in calyx of Held. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnc1 Products(1)

mRNA	Protein	Name
NM_012856.2	NP_036988.1	potassium voltage-gated channel subfamily C member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	12954870	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12805291	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	10482766	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	10482766	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	10482766	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11543764	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	9526005	RGD
involved in corpus callosum development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in globus pallidus development	IEP IEP: Inferred from expression pattern	10482766	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in positive regulation of monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	7472324	RGD
involved in positive regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	8436968	RGD
involved in positive regulation of voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	21943417	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	12954870	RGD
involved in regulation of monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	21541302	RGD
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	14679187	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	18775767	RGD
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	20219640	RGD
involved in response to fibroblast growth factor	IEP IEP: Inferred from expression pattern	9526005	RGD
involved in response to light intensity	IEP IEP: Inferred from expression pattern	18708127	RGD
involved in response to nerve growth factor	IEP IEP: Inferred from expression pattern	9526005	RGD
involved in response to potassium ion	IEP IEP: Inferred from expression pattern	9526005	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	18775767	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in calyx of Held	IDA IDA: Inferred from direct assay	14614103	RGD
located in cell surface	IDA IDA: Inferred from direct assay	18256021	RGD
located in dendrite	IDA IDA: Inferred from direct assay	11494252	RGD
located in neuron projection membrane	IDA IDA: Inferred from direct assay	18256021	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11494252	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	12954870	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	14614103	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14614103	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	12954870	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily C member 1

NGK2	Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991)
RAW2	potassium channel, voltage gated Shaw-related subfamily C, member 1
potassium voltage gated channel, Shaw-related subfamily, member 1	voltage-gated potas

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07108	KCNC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnc1	NCBI	NCBI:3746

Name
Email *

	Sorry, but the email address you supplied was invalid.