Kcnc1 - potassium voltage-gated channel subfamily C member 1 Gene

Also Known as Kv4; Kv3.1; KShIIIB; NGK2-KV4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25327

Summary

Enables delayed rectifier Potassium Channel activity; transmembrane transporter binding activity; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including brain development; positive regulation of voltage-gated Potassium Channel activity; and response to auditory stimulus. Located in several cellular components, including dendrite; neuron projection membrane; and neuronal cell body membrane. Part of voltage-gated Potassium Channel complex. Is active in calyx of Held. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnc1 Products (1)

mRNA Protein Name
NM_012856.2 NP_036988.1 potassium voltage-gated channel subfamily C member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
12954870 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12805291 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
10482766 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
10482766 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
10482766 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11543764 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
9526005 RGD
involved in corpus callosum development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in globus pallidus development IEP
IEP: Inferred from expression pattern
10482766 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in positive regulation of monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
7472324 RGD
involved in positive regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
8436968 RGD
involved in positive regulation of voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
21943417 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
12954870 RGD
involved in regulation of monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
21541302 RGD
involved in regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
14679187 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
18775767 RGD
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
20219640 RGD
involved in response to fibroblast growth factor IEP
IEP: Inferred from expression pattern
9526005 RGD
involved in response to light intensity IEP
IEP: Inferred from expression pattern
18708127 RGD
involved in response to nerve growth factor IEP
IEP: Inferred from expression pattern
9526005 RGD
involved in response to potassium ion IEP
IEP: Inferred from expression pattern
9526005 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
18775767 RGD
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
14614103 RGD
located in cell surface IDA
IDA: Inferred from direct assay
18256021 RGD
located in dendrite IDA
IDA: Inferred from direct assay
11494252 RGD
located in neuron projection membrane IDA
IDA: Inferred from direct assay
18256021 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11494252 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
12954870 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
14614103 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
14614103 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
12954870 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily C member 1

  • NGK2

  • Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991)

  • RAW2

  • potassium channel, voltage gated Shaw-related subfamily C, member 1

  • potassium voltage gated channel, Shaw-related subfamily, member 1

  • voltage-gated potas

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07108 KCNC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnc1 NCBI NCBI:3746