Adarb1 - adenosine deaminase, RNA-specific, B1 Gene

Rattus norvegicus

Also known as Red1; Adar2

Gene ID: 25367 | Gene type: protein coding

About Adarb1

Summary

This gene encodes a double-stranded-RNA-specific Adenosine Deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Adarb1 Products(4)

mRNA	Protein	Name
NM_001111055.1	NP_001104525.1	double-stranded RNA-specific editase 1 isoform 2
NM_001111056.1	NP_001104526.1	double-stranded RNA-specific editase 1 isoform 3
NM_001111057.1	NP_001104527.1	double-stranded RNA-specific editase 1 isoform 4
NM_012894.2	NP_037026.2	double-stranded RNA-specific editase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	10836790	RGD
enables double-stranded RNA adenosine deaminase activity	IDA IDA: Inferred from direct assay	8559253	RGD
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	16472753	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16682559	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23275536	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenosine to inosine editing	IDA IDA: Inferred from direct assay	8559253	RGD
involved in base conversion or substitution editing	IDA IDA: Inferred from direct assay	10836790	RGD
involved in mRNA modification	IDA IDA: Inferred from direct assay	14660658	RGD
involved in positive regulation of mRNA processing	IDA IDA: Inferred from direct assay	10331393	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	14612560	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

double-stranded RNA-specific editase 1

RNA editing deaminase of glutamate receptors	RNA-editing deaminase 1
RNA-editing enzyme 1	double stranded RNA specific deaminase RED1
dsRNA adenosine deaminase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00318	ADARB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adarb1	NCBI	NCBI:104

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