BCAN - Bcan brevican Gene

Also Known as BEHAB; ALPBRE

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25393

Summary

Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in cell-matrix adhesion; nervous system development; and regulation of neuronal synaptic plasticity. Located in several cellular components, including dendrite; main axon; and perineuronal net. Is anchored component of membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Used to study high grade glioma. Biomarker of high grade glioma and middle cerebral artery infarction. Orthologous to human BCAN (brevican). [provided by Alliance of Genome Resources, Apr 2022]

BCAN Products (2)

mRNA Protein Name
NM_001033665.1 NP_001028837.1 brevican core protein isoform 1 precursor
NM_012916.2 NP_037048.2 brevican core protein isoform 2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cell-matrix adhesion IDA
IDA: Inferred from direct assay
11208904 RGD
involved in gliogenesis IEP
IEP: Inferred from expression pattern
7869103 RGD
involved in neuron projection extension IDA
IDA: Inferred from direct assay
11208904 RGD
involved in regulation of neuronal synaptic plasticity IEP
IEP: Inferred from expression pattern
15935069 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
16503162 RGD
located in axon IDA
IDA: Inferred from direct assay
17709431 RGD
located in axon initial segment IDA
IDA: Inferred from direct assay
17709431 RGD
located in cell surface IDA
IDA: Inferred from direct assay
12799382 RGD
located in dendrite IDA
IDA: Inferred from direct assay
7592978 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
7592978 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16503162 RGD
located in node of Ranvier IDA
IDA: Inferred from direct assay
17709431 RGD
located in perineuronal net IDA
IDA: Inferred from direct assay
16644727 RGD
is active in perisynaptic extracellular matrix IDA
IDA: Inferred from direct assay
10414531 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
7592978 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

brevican core protein

  • brain-enriched hyaluronan-binding protein

  • brevican (brain specific proteoglycan in the aggrecan family)

  • brevican core protein-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18912 Bcan Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-166833 DOPE-PEG5000-Rhodamine B / Unkown
HY-RS01394 BCAN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25403 Bcan Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens BCAN NCBI NCBI:63827