Nfkbia - NFKB inhibitor alpha Gene

Also Known as RL/IF-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25493

Summary

Enables NF-kappaB binding activity and heat shock protein binding activity. Involved in several processes, including cytoplasmic sequestering of NF-kappaB; leukocyte migration involved in inflammatory response; and liver regeneration. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol and nucleus. Part of protein-containing complex. Used to study gastritis; pulmonary emphysema; and sciatic neuropathy. Biomarker of several diseases, including acute necrotizing pancreatitis; alcoholic hepatitis; artery disease (multiple); middle cerebral artery infarction; and toxic shock syndrome. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; hematologic Cancer (multiple); hepatitis B; hepatitis C; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbia Products (1)

mRNA Protein Name
NM_001105720.2 NP_001099190.2 NF-kappa-B inhibitor alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
16135962 RGD
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
16135962 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
12672265 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
19414010 RGD
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19414010 RGD
involved in cytoplasmic sequestering of NF-kappaB IMP
IMP: Inferred from mutant phenotype
9343439 RGD
involved in leukocyte migration involved in inflammatory response IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
24446557 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
19414010 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16135962 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NF-kappa-B inhibitor alpha

  • I-kappa-B-alpha

  • Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha

  • ikB-alpha

  • ikappaBalpha

  • nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha

  • nuclear factor of kappa light polypeptide gene enhan

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09260 NFKBIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18565 Nfkbia Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25048 Nfkbia Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkbia NCBI NCBI:4792