TAC4 - tachykinin precursor 4 Gene

Homo sapiens

Also known as EK; HK1; HK-1; PPT-C

Gene ID: 255061 | Gene type: protein coding

About TAC4

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,838,300-49,848,069 (from NCBI)

This gene has 8 transcripts (splice variants) and 66 orthologues. Low expression observed in reference dataset.

Summary

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted Peptides that activate members of a family of Receptor Proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TAC4 Products(5)

mRNA	Protein	Name
NM_001077503.2	NP_001070971.1	tachykinin-4 isoform beta precursor
NM_001077504.2	NP_001070972.1	tachykinin-4 isoform gamma precursor
NM_001077505.2	NP_001070973.1	tachykinin-4 isoform delta precursor
NM_001077506.2	NP_001070974.1	tachykinin-4 isoform alpha-2 precursor
NM_170685.3	NP_733786.2	tachykinin-4 isoform alpha precursor

Protein Preferred Names

Protein Names

tachykinin-4

endokinin

Related Diseases

Diseases

Alias

Oliver-Mcfarlane Syndrome

Trichomegaly-Retina Pigmentary Degeneration-Dwarfism Syndrome	OMCS
Long Eyelashes-Intellectual Disability Syndrome	Trichomegaly With Mental Retardation, Dwarfism, And Pigmentary Degeneration Of Retina
Eyelashes, Long, With Mental Retardation	Eyelashes Long Mental Retardation
Trichomegaly With Intellectual Disability, Dwarfism And Pigmentary Degeneration	Trichomegaly With Intellectual Disability, Dwarfism And Pigmentary Degeneration Of Retina
Eyelashes, Long With Intellectual Disability	Oliver Mcfarlane Syndrome
Congenital Trichomegaly, Pigmentary Retinal Degeneration, And Short Stature	Trichomegaly, Retina Pigmentary Degeneration, Dwarfism
Trichomegaly Retina Pigmentary Degeneration Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14138	TAC4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAC4	VGNC	VGNC:55826
Rattus norvegicus	TAC4	RGD	RGD:628842
Mus musculus	TAC4	MGD	MGI:1931130
Felis catus	TAC4	VGNC	VGNC:65917