Phex - phosphate regulating endopeptidase X-linked Gene

Also Known as PEX

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25512

Summary

Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; cellular response to vitamin D; and response to insulin-like growth factor stimulus. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in X-linked dominant hypophosphatemic rickets. Orthologous to human PHEX (phosphate regulating endopeptidase homolog X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Phex Products (1)

mRNA Protein Name
NM_013004.2 NP_037136.2 phosphate-regulating neutral endopeptidase PHEX

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in bone development IEP
IEP: Inferred from expression pattern
11064151 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
21826652 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
15337762 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
11064151 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
11064151 RGD
involved in response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
11064151 RGD
involved in response to sodium phosphate IEP
IEP: Inferred from expression pattern
11051050 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
14693675 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphate-regulating neutral endopeptidase PHEX

  • Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH)

  • metalloendopeptidase homolog PEX

  • metalloendopeptidase homolog PEX-like

  • phosphate regulating endopeptidase homolog, X-linked

  • phosphate regulating gene with h

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0050 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester 96.38% Unkown
HY-RS10412 PHEX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phex NCBI NCBI:5251