2. Gene
  3. Phex - phosphate regulating endopeptidase X-linked Gene

Phex - phosphate regulating endopeptidase X-linked Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PEX

Gene ID: 25512 | Gene type: protein coding

About Phex

Summary

Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; cellular response to vitamin D; and response to insulin-like growth factor stimulus. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in X-linked dominant hypophosphatemic rickets. Orthologous to human PHEX (phosphate regulating endopeptidase homolog X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Phex Products(1)

mRNA Protein Name
NM_013004.2 NP_037136.2 phosphate-regulating neutral endopeptidase PHEX
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in bone development IEP
IEP: Inferred from expression pattern
11064151 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
21826652 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
15337762 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
11064151 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
11064151 RGD
involved in response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
11064151 RGD
involved in response to sodium phosphate IEP
IEP: Inferred from expression pattern
11051050 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
14693675 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphate-regulating neutral endopeptidase PHEX

Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH)

metalloendopeptidase homolog PEX

metalloendopeptidase homolog PEX-like

phosphate regulating endopeptidase homolog, X-linked

phosphate regulating gene with h

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D0050 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester / Unkown
HY-RS10412 PHEX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phex NCBI NCBI:5251