Pou1f1 - POU class 1 homeobox 1 Gene

Rattus norvegicus

Also known as GHF1; Pit1; GHF1A; PIT1Z

Gene ID: 25517 | Gene type: protein coding

About Pou1f1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in adenohypophysis development; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pou1f1 Products(1)

mRNA	Protein	Name
NM_013008.3	NP_037140.2	pituitary-specific positive transcription factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	19887646	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	19887646	RGD
enables lncRNA binding	IDA IDA: Inferred from direct assay	30982661	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9685346	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenohypophysis development	IMP IMP: Inferred from mutant phenotype	16216912	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17021049	RGD
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16030140	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8370519	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8370519	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19887646	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IMP IMP: Inferred from mutant phenotype	16030140	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pituitary-specific positive transcription factor 1

GHF-1	POU domain, class 1, transcription factor 1
Pituary specific transcription factor 1 (growth hormone factor 1)	growth hormone factor 1
homeodomain protein for Growth Hormone (GH)	pit-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10895	POU1F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou1f1	NCBI	NCBI:5449

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