Pou1f1 - POU class 1 homeobox 1 Gene

Also Known as GHF1; Pit1; GHF1A; PIT1Z

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25517

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in adenohypophysis development; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pou1f1 Products (1)

mRNA Protein Name
NM_013008.3 NP_037140.2 pituitary-specific positive transcription factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
19887646 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
19887646 RGD
enables lncRNA binding IDA
IDA: Inferred from direct assay
30982661 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9685346 RGD
Biological Process GO Annotation Evidence References Source
involved in adenohypophysis development IMP
IMP: Inferred from mutant phenotype
16216912 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17021049 RGD
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16030140 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8370519 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8370519 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19887646 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IMP
IMP: Inferred from mutant phenotype
16030140 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pituitary-specific positive transcription factor 1

  • GHF-1

  • POU domain, class 1, transcription factor 1

  • Pituary specific transcription factor 1 (growth hormone factor 1)

  • growth hormone factor 1

  • homeodomain protein for Growth Hormone (GH)

  • pit-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10895 POU1F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pou1f1 NCBI NCBI:5449