Hnf1b - HNF1 homeobox B Gene

Rattus norvegicus

Also known as Tcf2; LF-B3; VHNF1; HNF-1B; HNF-1-beta

Gene ID: 25640 | Gene type: protein coding

About Hnf1b

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; protein-DNA complex assembly; and regulation of gene expression. Located in nucleus. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B). [provided by Alliance of Genome Resources, Apr 2022]

Hnf1b Products(3)

mRNA	Protein	Name
NM_001308148.1	NP_001295077.1	hepatocyte nuclear factor 1-beta isoform 1
NM_001308149.1	NP_001295078.1	hepatocyte nuclear factor 1-beta isoform 3
NM_013103.2	NP_037235.1	hepatocyte nuclear factor 1-beta isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12860991	RGD
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1673926	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	1673926	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	1673926	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12860991	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	9545279	RGD
involved in embryonic morphogenesis	IDA IDA: Inferred from direct assay	12860991	RGD
involved in hepatocyte differentiation	IEP IEP: Inferred from expression pattern	18286537	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12860991	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	1673926	RGD
involved in protein-DNA complex assembly	IMP IMP: Inferred from mutant phenotype	9545279	RGD
involved in response to biphenyl	IEP IEP: Inferred from expression pattern	12051991	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	10580588	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18656965	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 1-beta

Transcription factor 2, hepatic

variant hepatic nuclear factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06256	HNF1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174668	Human HNF1B mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnf1b	NCBI	NCBI:6928

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