2. Gene
  3. Gja4 - gap junction protein, alpha 4 Gene

Gja4 - gap junction protein, alpha 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CXN37; Cxnh1

Gene ID: 25655 | Gene type: protein coding

About Gja4

Summary

Predicted to enable gap junction channel activity. Involved in several processes, including calcium ion transport; endothelium development; and response to pain. Located in gap junction. Part of connexin complex. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human GJA4 (Gap Junction Protein alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Gja4 Products(1)

mRNA Protein Name
NM_021654.2 NP_067686.1 gap junction alpha-4 protein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
15319213 RGD
involved in cell-cell signaling IMP
IMP: Inferred from mutant phenotype
15319213 RGD
involved in endothelium development IEP
IEP: Inferred from expression pattern
10990491 RGD
involved in response to pain IEP
IEP: Inferred from expression pattern
11978404 RGD
Cellular Component GO Annotation Evidence Reference Source
part of connexin complex IDA
IDA: Inferred from direct assay
9851942 RGD
located in gap junction IDA
IDA: Inferred from direct assay
10894813 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gap junction alpha-4 protein

Gap junction membrane channel, protein alpha 4 (connexin 37)

connexin h1

connexin-37

cx37

gap junction membrane channel protein alpha 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05443 GJA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gja4 NCBI NCBI:2701