2. Gene
  3. Clcn5 - chloride voltage-gated channel 5 Gene

Clcn5 - chloride voltage-gated channel 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CLC5

Gene ID: 25749 | Gene type: protein coding

About Clcn5

Summary

Enables voltage-gated Chloride Channel activity. Involved in chloride transport. Located in endosome and membrane. Used to study renal tubular transport disease. Human ortholog(s) of this gene implicated in Dent disease; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to human CLCN5 (chloride voltage-gated channel 5). [provided by Alliance of Genome Resources, Apr 2022]

Clcn5 Products(2)

mRNA Protein Name
NM_001414393.1 NP_001401322.1 H(+)/Cl(-) exchange transporter 5 isoform 1
NM_017106.2 NP_058802.2 H(+)/Cl(-) exchange transporter 5 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables voltage-gated chloride channel activity IDA
IDA: Inferred from direct assay
8626585 RGD
Biological Process GO Annotation Evidence Reference Source
involved in chloride transport IDA
IDA: Inferred from direct assay
8626585 RGD
Cellular Component GO Annotation Evidence Reference Source
located in endosome IDA
IDA: Inferred from direct assay
9815133 RGD
located in membrane IDA
IDA: Inferred from direct assay
14675051 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H(+)/Cl(-) exchange transporter 5

chloride channel 5

chloride channel protein 5

chloride channel, voltage-sensitive 5

chloride transporter ClC-5

clC-5

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02757 CLCN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clcn5 NCBI NCBI:1184