Clcn5 - chloride voltage-gated channel 5 Gene

Also Known as CLC5

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25749

Summary

Enables voltage-gated Chloride Channel activity. Involved in chloride transport. Located in endosome and membrane. Used to study renal tubular transport disease. Human ortholog(s) of this gene implicated in Dent disease; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to human CLCN5 (chloride voltage-gated channel 5). [provided by Alliance of Genome Resources, Apr 2022]

Clcn5 Products (2)

mRNA Protein Name
NM_001414393.1 NP_001401322.1 H(+)/Cl(-) exchange transporter 5 isoform 1
NM_017106.2 NP_058802.2 H(+)/Cl(-) exchange transporter 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables voltage-gated chloride channel activity IDA
IDA: Inferred from direct assay
8626585 RGD
Biological Process GO Annotation Evidence References Source
involved in chloride transport IDA
IDA: Inferred from direct assay
8626585 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
9815133 RGD
located in membrane IDA
IDA: Inferred from direct assay
14675051 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H(+)/Cl(-) exchange transporter 5

  • chloride channel 5

  • chloride channel protein 5

  • chloride channel, voltage-sensitive 5

  • chloride transporter ClC-5

  • clC-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02757 CLCN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clcn5 NCBI NCBI:1184