Erc2 - ELKS/RAB6-interacting/CAST family member 2 Gene

Rattus norvegicus

Also known as CAST; Cmbp

Gene ID: 259269 | Gene type: protein coding

About Erc2

Summary

Enables PDZ domain binding activity. Involved in synapse organization. Located in several cellular components, including distal axon; postsynaptic density; and presynaptic membrane. Part of protein-containing complex. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC2 (ELKS/RAB6-interacting/CAST family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Erc2 Products(2)

mRNA	Protein	Name
NM_001401498.1	NP_001388427.1	ERC protein 2 isoform 1
NM_170787.3	NP_740768.1	ERC protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	12163476	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12163476	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12163476	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in synapse organization	IEP IEP: Inferred from expression pattern	12163476	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	22875941	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12163476	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12163476	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	22875941	RGD
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	12391317	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	12163476	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12163476	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	12163476	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ERC protein 2

CAST1	CAZ-associated structural protein 1
cytomatrix protein p110

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04477	ERC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erc2	NCBI	NCBI:26059

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