DNM3 - dynamin 3 Gene

Homo sapiens

Also known as Dyna III

Gene ID: 26052 | Gene type: protein coding

About DNM3

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,841,498-172,418,466 (from NCBI)

This gene has 9 transcripts (splice variants), 191 orthologues and 6 paralogues. Biased expression in brain (RPKM 10.0), adrenal (RPKM 2.5) and 8 other tissues.

Summary

This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

DNM3 Products(6)

mRNA	Protein	Name
NM_001136127.3	NP_001129599.1	dynamin-3 isoform b
NM_001278252.2	NP_001265181.1	dynamin-3 isoform c
NM_001350204.2	NP_001337133.1	dynamin-3 isoform d
NM_001350205.2	NP_001337134.1	dynamin-3 isoform e
NM_001350206.2	NP_001337135.1	dynamin-3 isoform f
NM_015569.5	NP_056384.2	dynamin-3 isoform a

DNM3 Protein Structure

Dynamin_N

Dynamin_M

GED

0
200
400
600
800
869 a.a.

Protein Preferred Names

Protein Names

dynamin-3

T-dynamin

Related Diseases

Diseases

Alias

Autosomal Dominant Optic Atrophy Plus Syndrome

Cerebellar Ataxia-Areflexia-Pes Cavus-Optic Atrophy-Sensorineural Hearing Loss Syndrome	Capos Syndrome
Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy	Optic Atrophy-Deafness-Polyneuropathy-Myopathy Syndrome
Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy And Sensorinural Hearing	Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy And Sensorinural Hearing Loss
Capos	Cerebellar Ataxia - Areflexia - Pes Cavus - Optic Atrophy - Sensorineural Hearing Loss
Dominant Optic Atrophy Plus Syndrome	Dominant Optic Atrophy, Deafness, Ptosis, Ophthalmoplegia, Dystaxia, And Myopathy
Optic Atrophy - Deafness- Polyneuropathy - Myopathy	Treft-Sanborn-Carey Syndrome
Doa+	Optic Atrophy-Hearing Loss-Polyneuropathy-Myopathy Syndrome
Cerebellar Ataxia-Areflexia-Pes Cavus-Optic Atrophy-Sensorineural Deafness Syndrome	Optic Atrophy Autosomal Dominant
Treft Sanborn Carey Syndrome

Neuropathy, Hereditary Sensory, Type Id

HSN1D	Hereditary Sensory Neuropathy Type 1d
Neuropathy, Hereditary Sensory, Type 1d	Neuropathy, Hereditary Sensory, 1d
Hereditary Sensory Neuropathy Type Id	Neuropathy, Sensory, Hereditary, Type Id

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03906	DNM3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DNM3	VGNC	VGNC:40034
Felis catus	DNM3	VGNC	VGNC:107868
Rattus norvegicus	DNM3	RGD	RGD:727949
Macaca mulatta	DNM3	VGNC	VGNC:71928
Bos taurus	DNM3	VGNC	VGNC:106714
Mus musculus	DNM3	MGD	MGI:1341299