DNM3 - dynamin 3 Gene

Also Known as Dyna III

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26052

About DNM3

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,841,498-172,418,466 (from NCBI)

This gene has 9 transcripts (splice variants), 191 orthologues and 6 paralogues. Biased expression in brain (RPKM 10.0), adrenal (RPKM 2.5) and 8 other tissues.

Summary

This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

DNM3 Products (6)

mRNA	Protein	Name
NM_001136127.3	NP_001129599.1	dynamin-3 isoform b
NM_001278252.2	NP_001265181.1	dynamin-3 isoform c
NM_001350204.2	NP_001337133.1	dynamin-3 isoform d
NM_001350205.2	NP_001337134.1	dynamin-3 isoform e
NM_001350206.2	NP_001337135.1	dynamin-3 isoform f
NM_015569.5	NP_056384.2	dynamin-3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26302298	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15252009	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNM3 Protein Structure

Dynamin_N

Dynamin_M

PH

GED

0
200
400
600
800
869 a.a.

Protein Preferred Names	Protein Names
dynamin-3	T-dynamin

DNM3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P83234	Dynamin 3 Antibody (YA2979)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Autosomal Dominant Optic Atrophy Plus Syndrome	Cerebellar Ataxia-Areflexia-Pes Cavus-Optic Atrophy-Sensorineural Hearing Loss Syndrome Capos Syndrome Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy Optic Atrophy-Deafness-Polyneuropathy-Myopathy Syndrome Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy And Sensorinural Hearing Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy And Sensorinural Hearing Loss Capos Cerebellar Ataxia - Areflexia - Pes Cavus - Optic Atrophy - Sensorineural Hearing Loss Dominant Optic Atrophy Plus Syndrome Dominant Optic Atrophy, Deafness, Ptosis, Ophthalmoplegia, Dystaxia, And Myopathy Optic Atrophy - Deafness- Polyneuropathy - Myopathy Treft-Sanborn-Carey Syndrome Doa+ Optic Atrophy-Hearing Loss-Polyneuropathy-Myopathy Syndrome Cerebellar Ataxia-Areflexia-Pes Cavus-Optic Atrophy-Sensorineural Deafness Syndrome Optic Atrophy Autosomal Dominant Treft Sanborn Carey Syndrome
Neuropathy, Hereditary Sensory, Type Id	HSN1D Hereditary Sensory Neuropathy Type 1d Neuropathy, Hereditary Sensory, Type 1d Neuropathy, Hereditary Sensory, 1d Hereditary Sensory Neuropathy Type Id Neuropathy, Sensory, Hereditary, Type Id
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Alstrom Syndrome	ALMS Alström Syndrome Alss Alstrom-Hallgren Syndrome Alstroem Syndrome
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS03906	DNM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DNM3	VGNC	VGNC:40034
Felis catus	DNM3	VGNC	VGNC:107868
Rattus norvegicus	DNM3	RGD	RGD:727949
Macaca mulatta	DNM3	VGNC	VGNC:71928
Bos taurus	DNM3	VGNC	VGNC:106714
Mus musculus	DNM3	MGD	MGI:1341299
Others	DNM3	NCBI