TANC2 - tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Gene

Also Known as rols; ROLSA; IDDALDS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26115

About TANC2

Cytogenetic location: 17q23.2-q23.3 Genomic coordinates (GRCh38): 17:62,966,235-63,427,703 (from NCBI)

This gene has 11 transcripts (splice variants), 280 orthologues, 4 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 6.5), testis (RPKM 5.9) and 23 other tissues.

Summary

Predicted to be involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Predicted to act upstream of or within in utero embryonic development. Located in dendritic spine. [provided by Alliance of Genome Resources, Apr 2022]

TANC2 Products (3)

mRNA	Protein	Name
NM_001394998.1	NP_001381927.1	protein TANC2 isoform 2
NM_001411076.1	NP_001398005.1	protein TANC2 isoform 3
NM_025185.4	NP_079461.2	protein TANC2 isoform 1

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	30021165	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TANC2 Protein Structure

Ank_2

Ank

Ank_2

Ank

TPR_11

0
400
800
1200
1600
1990 a.a.

Protein Preferred Names	Protein Names
protein TANC2	putative ankyrin-repeat containing protein

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder With Autistic Features And Language Delay, With Or Without Seizures	IDDALDS Intellectual Developmental Disorder With Autistic Features And Language Delay Without Seizures
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14195	TANC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TANC2	VGNC	VGNC:47099
Felis catus	TANC2	VGNC	VGNC:65949
Rattus norvegicus	TANC2	RGD	RGD:1309285
Bos taurus	TANC2	VGNC	VGNC:35592
Mus musculus	TANC2	MGD	MGI:2444121
Macaca mulatta	TANC2	VGNC	VGNC:99281
Others	TANC2	NCBI