Gulo - gulonolactone (L-) oxidase Gene

Also Known as GLO; LGO; sfx; unh; unhip; 5730581M22

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268756

Summary

Enables L-gulonolactone oxidase activity and flavin adenine dinucleotide binding activity. Involved in L-ascorbic acid biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including cranium; liver; nasal septum; nervous system; and pancreas. Human ortholog(s) of this gene implicated in scurvy. Orthologous to human GULOP (gulonolactone (L-) oxidase, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]

Gulo Products (1)

mRNA Protein Name
NM_178747.3 NP_848862.1 L-gulonolactone oxidase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-gulonolactone oxidase activity IDA
IDA: Inferred from direct assay
10606751 MGI
enables L-gulonolactone oxidase activity IMP
IMP: Inferred from mutant phenotype
10606751 MGI
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
14962674 MGI
Biological Process GO Annotation Evidence References Source
involved in L-ascorbic acid biosynthetic process IDA
IDA: Inferred from direct assay
14962674 MGI
acts upstream of or within L-ascorbic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
10639167 MGI
involved in L-ascorbic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
10606751 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

L-gulonolactone oxidase

  • L-gulono-gamma-lactone oxidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W040253 D-Glycero-D-gulo-heptono-1,4-lactone / Unkown