Dagla - diacylglycerol lipase, alpha Gene

Also Known as Nsddr

Species: Mus musculus

Gene Type: protein coding

Gene ID: 269060

Summary

Enables hydrolase activity. Involved in G protein-coupled glutamate receptor signaling pathway; regulation of neuroinflammatory response; and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within several processes, including arachidonic acid metabolic process; endocannabinoid signaling pathway; and neurotransmitter biosynthetic process. Located in dendritic spine membrane; postsynaptic membrane; and varicosity. Is integral component of postsynaptic membrane. Is expressed in brain and olfactory epithelium. Orthologous to human DAGLA (diacylglycerol Lipase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Dagla Products (1)

mRNA	Protein	Name
NM_198114.2	NP_932782.2	diacylglycerol lipase-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hydrolase activity	IMP IMP: Inferred from mutant phenotype	17584991	MGI
enables monoacylglycerol lipase activity	IMP IMP: Inferred from mutant phenotype	20147530	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17584991	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of arachidonate metabolic process	IMP IMP: Inferred from mutant phenotype	20147530	MGI
involved in arachidonate metabolic process	IMP IMP: Inferred from mutant phenotype	17584991	MGI
acts upstream of or within cannabinoid biosynthetic process	IMP IMP: Inferred from mutant phenotype	20147530	MGI
acts upstream of or within monoacylglycerol biosynthetic process	IMP IMP: Inferred from mutant phenotype	20147530	MGI
acts upstream of or within neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	20147530	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	20147530	MGI
involved in regulation of neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	26779719	MGI
involved in retrograde trans-synaptic signaling by endocannabinoid	IDA IDA: Inferred from direct assay	20159446	MGI
involved in retrograde trans-synaptic signaling by endocannabinoid	IMP IMP: Inferred from mutant phenotype	20147530	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in dendritic spine membrane	IDA IDA: Inferred from direct assay	16723519	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17584991	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	23011134	MGI
located in varicosity	IDA IDA: Inferred from direct assay	20962221	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
diacylglycerol lipase-alpha	DAGL-alpha DGL-alpha neural stem cell-derived dendrite regulator sn1-specific diacylglycerol lipase alpha

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4406	Abz-AGLA-Nba		99.71%	Unkown
HY-P4406A	Abz-AGLA-Nba TFA		99.64%	Unkown
HY-RS03520	DAGLA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dagla	NCBI	NCBI:747