Ell3 - elongation factor RNA polymerase II-like 3 Gene

Also Known as A930015D22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 269344

Summary

Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of epithelial to mesenchymal transition; and transcription by RNA polymerase II. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of neural precursor cell proliferation; and positive regulation of neurogenesis. Located in nucleus. Is expressed in embryo endoderm and olfactory epithelium. Orthologous to human ELL3 (elongation factor for RNA polymerase II 3). [provided by Alliance of Genome Resources, Apr 2022]

Ell3 Products (1)

mRNA	Protein	Name
NM_145973.2	NP_666085.2	RNA polymerase II elongation factor ELL3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23273992	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23273992	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	22768269	MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	22768269	MGI
acts upstream of or within negative regulation of signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	22768269	MGI
acts upstream of neural precursor cell proliferation	IDA IDA: Inferred from direct assay	22768269	MGI
acts upstream of or within positive regulation of neural precursor cell proliferation	IDA IDA: Inferred from direct assay	22768269	MGI
acts upstream of or within positive regulation of neurogenesis	IDA IDA: Inferred from direct assay	22768269	MGI
acts upstream of or within positive regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	22768269	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23273992	MGI
involved in regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	22768269	MGI
acts upstream of signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	22768269	MGI
involved in stem cell differentiation	IMP IMP: Inferred from mutant phenotype	22768269	MGI
acts upstream of stem cell proliferation	IDA IDA: Inferred from direct assay	22768269	MGI
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23273992	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	23273992	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
RNA polymerase II elongation factor ELL3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04310	ELL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ell3	NCBI	NCBI:80237