Plekhg5 - pleckstrin homology domain containing, family G (with RhoGef domain) member 5 Gene

Mus musculus

Also known as Syx

Gene ID: 269608 | Gene type: protein coding

About Plekhg5

Summary

This gene encodes a protein belonging to the Rho guanine exchange factor (GEF) family of proteins, which activate GTPases by replacing GDP with GTP. This family member is a RhoA GEF that plays a role in endothelial cell migration and tube formation. It is required for angiogenesis and may function in neuronal cell differentiation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Plekhg5 Products(2)

mRNA	Protein	Name
NM_001285999.1	NP_001272928.1	pleckstrin homology domain-containing family G member 5 isoform 1
NM_001374783.1	NP_001361712.1	pleckstrin homology domain-containing family G member 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	16467373	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16467373	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	21543326	MGI
acts upstream of or within endothelial cell migration	IDA IDA: Inferred from direct assay	16467373	MGI
involved in regulation protein catabolic process at presynapse	IDA IDA: Inferred from direct assay	29084947	MGI
involved in regulation protein catabolic process at presynapse	IMP IMP: Inferred from mutant phenotype	29084947	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	21543326	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16467373	MGI
located in endocytic vesicle	IDA IDA: Inferred from direct assay	21543326	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	21543326	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16467373	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family G member 5

PH domain-containing family G member 5	RhoA-specific guanine exchange factor SYX1
RhoA-specific guanine exchange factor SYX2	synectin-binding RhoA exchange factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10693	PLEKHG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14813	TNFRSF25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plekhg5	NCBI	NCBI:57449

Name
Email *

	Sorry, but the email address you supplied was invalid.