Plekhg5 - pleckstrin homology domain containing, family G (with RhoGef domain) member 5 Gene

Also Known as Syx

Species: Mus musculus

Gene Type: protein coding
Gene ID: 269608

Summary

This gene encodes a protein belonging to the Rho guanine exchange factor (GEF) family of proteins, which activate GTPases by replacing GDP with GTP. This family member is a RhoA GEF that plays a role in endothelial cell migration and tube formation. It is required for angiogenesis and may function in neuronal cell differentiation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Plekhg5 Products (2)

mRNA Protein Name
NM_001285999.1 NP_001272928.1 pleckstrin homology domain-containing family G member 5 isoform 1
NM_001374783.1 NP_001361712.1 pleckstrin homology domain-containing family G member 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
16467373 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16467373 MGI
Biological Process GO Annotation Evidence References Source
involved in endothelial cell chemotaxis IMP
IMP: Inferred from mutant phenotype
21543326 MGI
acts upstream of or within endothelial cell migration IDA
IDA: Inferred from direct assay
16467373 MGI
involved in regulation protein catabolic process at presynapse IDA
IDA: Inferred from direct assay
29084947 MGI
involved in regulation protein catabolic process at presynapse IMP
IMP: Inferred from mutant phenotype
29084947 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
21543326 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16467373 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
21543326 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
21543326 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16467373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family G member 5

  • PH domain-containing family G member 5

  • RhoA-specific guanine exchange factor SYX1

  • RhoA-specific guanine exchange factor SYX2

  • synectin-binding RhoA exchange factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10693 PLEKHG5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14813 TNFRSF25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plekhg5 NCBI NCBI:57449