2. Gene
  3. Tlx3 - T cell leukemia, homeobox 3 Gene

Tlx3 - T cell leukemia, homeobox 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rnx; Tlx1l2; Hox11l2

Gene ID: 27140 | Gene type: protein coding

About Tlx3

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; regulation of respiratory gaseous exchange by nervous system process; and respiratory gaseous exchange by respiratory system. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; ganglia; genitourinary system; and sensory organ. Used to study congenital central hypoventilation syndrome. Orthologous to human TLX3 (T cell leukemia homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Tlx3 Products(1)

mRNA Protein Name
NM_019916.2 NP_064300.2 T-cell leukemia homeobox protein 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15466398 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of GABAergic neuron differentiation IGI
IGI: Inferred from genetic interaction
16234809 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
12023301 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
16234809 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
12023301 MGI
acts upstream of or within neuron fate specification IGI
IGI: Inferred from genetic interaction
15064766 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
15064766 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15229182 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IMP
IMP: Inferred from mutant phenotype
15527896 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: Inferred from mutant phenotype
10700185 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
15466398 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell leukemia homeobox protein 3

homeo box 11-like 2

homeobox TLX-3

homeobox protein Hox-11L2

respiratory neuron homeobox protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14604 TLX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlx3 NCBI NCBI:30012