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Trp53bp1 - transformation related protein 53 binding protein 1 Gene

Also Known as 53BP1; m53BP1; p53BP1; Tp53bp1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 27223

Summary

Enables damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype switching. Acts upstream of or within DNA repair. Located in chromosome and nuclear body. Part of DNA repair complex. Is expressed in ileum; lung; metanephros; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Trp53bp1 Products (2)

mRNA	Protein	Name
NM_001290830.1	NP_001277759.1	TP53-binding protein 1 isoform b
NM_013735.4	NP_038763.3	TP53-binding protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables damaged DNA binding	IDA IDA: Inferred from direct assay	11934988	MGI
enables methylated histone binding	IDA IDA: Inferred from direct assay	23209566	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8910340	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23241889	MGI
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	17053789	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA repair	IDA IDA: Inferred from direct assay	15364958	MGI
involved in double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	20362325	MGI
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	23333305	MGI
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	20362325	MGI
involved in negative regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	23333305	MGI
involved in positive regulation of isotype switching	IMP IMP: Inferred from mutant phenotype	15077110	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of DNA repair complex	IDA IDA: Inferred from direct assay	24217620	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	19001091	MGI
located in kinetochore	IDA IDA: Inferred from direct assay	11801725	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	21746928	MGI
located in nucleus	IDA IDA: Inferred from direct assay	24001775	MGI
located in replication fork	IDA IDA: Inferred from direct assay	15364958	MGI
located in site of double-strand break	IDA IDA: Inferred from direct assay	23209566	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
TP53-binding protein 1	murine p53-binding protein p53-binding protein 1 tumor suppressor p53-binding protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14915	TP53BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown