DHDH - dihydrodiol dehydrogenase Gene

Homo sapiens

Also known as 2DD; HUM2DD

Gene ID: 27294 | Gene type: protein coding

About DHDH

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,932,795-48,944,969 (from NCBI)

This gene has 4 transcripts (splice variants), 287 orthologues and 3 paralogues. Biased expression in kidney (RPKM 7.4), small intestine (RPKM 4.3) and 5 other tissues.

Summary

This gene encodes an Enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This Enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]

DHDH Products(1)

mRNA	Protein	Name
NM_014475.4	NP_055290.1	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

DHDH Protein Structure

GFO_IDH_MocA

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

3-deoxyglucosone reductase

Related Diseases

Diseases

Alias

Congenital Myasthenic Syndrome 7

Cms7	Congenital Myasthenic Syndrome 7 Presynaptic
Myasthenic Syndrome, Congenital, Type 7, Presynaptic

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03729	DHDH Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DHDH	VGNC	VGNC:39929
Rattus norvegicus	DHDH	RGD	RGD:1588686
Mus musculus	DHDH	MGD	MGI:1919005
Bos taurus	DHDH	VGNC	VGNC:28036
Macaca mulatta	DHDH	VGNC	VGNC:71653