2. Gene
  3. Msrb1 - methionine sulfoxide reductase B1 Gene

Msrb1 - methionine sulfoxide reductase B1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SELX; SelR; Sepr; Sepx1; D17Wsu82e

Gene ID: 27361 | Gene type: protein coding

About Msrb1

Summary

The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair Enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to Other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2016]

Msrb1 Products(2)

mRNA Protein Name
NM_001346668.1 NP_001333597.1 methionine-R-sulfoxide reductase B1
NM_013759.3 NP_038787.1 methionine-R-sulfoxide reductase B1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin binding IDA
IDA: Inferred from direct assay
23911929 MGI
enables peptide-methionine (R)-S-oxide reductase activity IDA
IDA: Inferred from direct assay
14699060 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
14699060 MGI
Biological Process GO Annotation Evidence Reference Source
involved in actin filament polymerization IDA
IDA: Inferred from direct assay
23911929 MGI
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
23911929 MGI
acts upstream of or within protein repair IDA
IDA: Inferred from direct assay
14699060 MGI
involved in protein repair IDA
IDA: Inferred from direct assay
14699060 MGI
Cellular Component GO Annotation Evidence Reference Source
colocalizes with actin cytoskeleton IDA
IDA: Inferred from direct assay
23911929 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
14699060 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14699060 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methionine-R-sulfoxide reductase B1

selenoprotein R

selenoprotein X 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08726 MSRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Msrb1 NCBI NCBI:51734