AQP11 - aquaporin 11 Gene

Also Known as AQPX1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 282679

About AQP11

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:77,589,953-77,610,356 (from NCBI)

This gene has 2 transcripts (splice variants), 246 orthologues and 2 paralogues. Biased expression in duodenum (RPKM 12.3), small intestine (RPKM 11.2) and 11 other tissues.

Summary

Enables glycerol channel activity and water channel activity. Involved in several processes, including glycerol transport; hydrogen peroxide transmembrane transport; and protein homooligomerization. Located in cell surface; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AQP11 Products (2)

mRNA Protein Name
NM_001363477.2 NP_001350406.1 aquaporin-11 isoform 2
NM_173039.3 NP_766627.1 aquaporin-11 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycerol channel activity IMP
IMP: Inferred from mutant phenotype
24845055 GOA
enables hydrogen peroxide channel activity IDA
IDA: Inferred from direct assay
31546170 GOA
enables water channel activity IDA
IDA: Inferred from direct assay
24918044 GOA
enables water channel activity IMP
IMP: Inferred from mutant phenotype
24845055 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in glycerol transmembrane transport IDA
IDA: Inferred from direct assay
16650285 GOA
involved in glycerol transmembrane transport IMP
IMP: Inferred from mutant phenotype
24845055 GOA
involved in hydrogen peroxide transmembrane transport IMP
IMP: Inferred from mutant phenotype
31546170 GOA
involved in intracellular water homeostasis IDA
IDA: Inferred from direct assay
24918044 GOA
involved in intracellular water homeostasis IMP
IMP: Inferred from mutant phenotype
24845055 GOA
NOT involved in monoatomic ion transport IDA
IDA: Inferred from direct assay
16650285 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
30563120 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
24918044 GOA
NOT involved in urea transport IDA
IDA: Inferred from direct assay
16650285 GOA
NOT involved in water transport IDA
IDA: Inferred from direct assay
16650285 GOA
involved in water transport IMP
IMP: Inferred from mutant phenotype
24845055 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
16650285 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24918044 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
31546170 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP11 Protein Structure

MIP

MIP: Major intrinsic protein (77 - 250)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

aquaporin-11

  • AQP-11

Related Diseases

Diseases Alias
Nephrogenic Diabetes Insipidus

  • Vasopressin-Resistant Diabetes Insipidus

  • Diabetes Insipidus, Nephrogenic

  • Diabetes Insipidus Nephrogenic

  • Congenital Nephrogenic Diabetes Insipidus

  • Adh Resistant Diabetes Insipidus

  • Diabetes Insipidus Nephrogenic X-Linked

  • Diabetes Insipidus Nephrogenic Type 1

  • Adh-Resistant Diabetes Insipidus

  • Diabetes Insipidus Renalis

  • Ndi

  • Renal Diabetes Insipidus

  • Familial Nephrogenic Diabetes

  • Antidiuretic-Hormone-Resistant Diabetes Insipidus

  • Adiuretin-Resistant Diabetes Insipidus

  • Ndi - [Nephrogenic Diabetes Insipidus]

  • Diabetes Tenuifluus

  • Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus

  • Hereditary Nephrogenic Diabetes Insipidus

  • Familial Nephrogenic Diabetes Insipidus

  • Primary Nephrogenic Diabetes Insipidus
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110200 TC AQP1 1 Inhibitor 98.03% Unkown
HY-RS00873 AQP11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AQP11 VGNC VGNC:69866
Felis catus AQP11 VGNC VGNC:59860
Mus musculus AQP11 MGD MGI:1913583
Bos taurus AQP11 VGNC VGNC:26045
Rattus norvegicus AQP11 RGD RGD:628763
Canis familiaris AQP11 VGNC VGNC:38016
Others AQP11 NCBI