NEAT1 - nuclear paraspeckle assembly transcript 1 Gene
Also Known as VINC; TncRNA; TP53LC15; LINC00084; NCRNA00084
Species: Homo sapiens
About NEAT1
This gene has 9 transcripts (splice variants).
Summary
This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in Cancer progression. [provided by RefSeq, Mar 2015]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RISC complex binding |
IDA
IDA: Inferred from direct assay
|
28379604 | GOA |
| enables chromatin-protein adaptor activity |
IDA
IDA: Inferred from direct assay
|
25155612 | GOA |
| enables miRNA binding |
IDA
IDA: Inferred from direct assay
|
28379604 | GOA |
| enables miRNA inhibitor activity via base-pairing |
IDA
IDA: Inferred from direct assay
|
28379604 | GOA |
| enables molecular condensate scaffold activity |
IMP
IMP: Inferred from mutant phenotype
|
19716791 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in lncRNA-mediated post-transcriptional gene silencing |
IDA
IDA: Inferred from direct assay
|
28379604 | GOA |
| involved in nuclear body organization |
IMP
IMP: Inferred from mutant phenotype
|
19716791 | GOA |
| involved in positive regulation of inflammatory response |
IMP
IMP: Inferred from mutant phenotype
|
28379604 | GOA |
| involved in positive regulation of miRNA catabolic process |
IMP
IMP: Inferred from mutant phenotype
|
28379604 | GOA |
| acts upstream of positive regulation of synoviocyte proliferation |
IMP
IMP: Inferred from mutant phenotype
|
28379604 | GOA |
| acts upstream of or within negative effect regulation of mRNA export from nucleus |
IMP
IMP: Inferred from mutant phenotype
|
19716791 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in paraspeckles |
IDA
IDA: Inferred from direct assay
|
19716791 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Dengue Disease |
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| Gastric Adenocarcinoma |
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| Relapsing-Remitting Multiple Sclerosis |
|
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| Kidney Disease |
|
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| Acquired Immunodeficiency Syndrome |
|
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| Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies |
|
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| Thyroid Carcinoma |
|
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| High Grade Glioma |
|
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| Leukemia |
|
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| Laryngeal Squamous Cell Carcinoma |
|
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| Huntington Disease |
|
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| Frontotemporal Dementia |
|
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| Degenerative Disc Disease |
|
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| Visual Epilepsy |
|
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| Immune Deficiency Disease |
|
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| Squamous Cell Carcinoma |
|
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| Nasopharyngeal Carcinoma |
|
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| Oral Squamous Cell Carcinoma |
|
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| Burkitt Lymphoma |
|
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| Systemic Lupus Erythematosus |
|
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| Thyroid Gland Papillary Carcinoma |
|
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| Glioma |
|
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| Cholangiocarcinoma |
|
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| Cervical Cancer |
|
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| Endometrial Cancer |
|
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| Parkinson Disease, Late-Onset |
|
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| Leukemia, Chronic Lymphocytic |
|
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| Osteogenic Sarcoma |
|
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| Acute Promyelocytic Leukemia |
|
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| Thyroid Cancer, Nonmedullary, 1 |
|
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| Amyotrophic Lateral Sclerosis 1 |
|
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| Pancreatic Cancer |
|
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| Ovarian Cancer |
|
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| Gastric Cancer |
|
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| Hepatocellular Carcinoma |
|
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| Prostate Cancer |
|
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| Lung Cancer |
|
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| Colorectal Cancer |
|
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| Breast Cancer |
|
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| Multiple Endocrine Neoplasia |
|
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| Bronchopneumonia |
|
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| Retinitis Pigmentosa 11 |
|
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| Retinitis Pigmentosa |
|
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