NOMO2 - NODAL modulator 2 Gene

Also Known as PM5; Nomo

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283820

About NOMO2

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:18,499,927-18,562,112 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 58.0), heart (RPKM 50.7) and 25 other tissues.

Summary

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

NOMO2 Products (2)

mRNA	Protein	Name
NM_001004060.2	NP_001004060.1	nodal modulator 2 isoform 1 precursor
NM_173614.4	NP_775885.1	nodal modulator 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17261586	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	32820719	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in multi-pass transmembrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	36261522	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17261586	GOA
part of multi-pass translocon complex	IDA IDA: Inferred from direct assay	36261522	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20538592	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOMO2 Protein Structure

CarboxypepD_reg

0
200
400
600
800
1000
1200
1267 a.a.

Protein Preferred Names	Protein Names
nodal modulator 2	pM5 protein 2

Related Diseases

Diseases	Alias
Pseudoxanthoma Elasticum	PXE Gronblad-Strandberg Syndrome Pseudoxanthoma Elasticum, Modifier Of Severity Of Gronblad-Strandberg-Touraine Syndrome Gronblad Strandberg Syndrome Groenblad-Strandberg Syndrome Nevus Elasticus Pxe - [Pseudoxanthoma Elasticum]
Superficial Urinary Bladder Cancer	Superficial Urinary Bladder Carcinoma Carcinoma Of Urinary Bladder, Superficial
Supraglottis Cancer	Malignant Tumor Of Supraglottis Supraglottis Ca Larynx - Supraglottis Malignant Neoplasm Of Extrinsic Larynx Malignant Neoplasm Of Supraglottis Malignant Supraglottic Tumor Neoplasm Of Supraglottis
Ulcerative Stomatitis	Stomatitis Ulcerative Aphthous Stomatitis Minor Oral Aphthous Ulceration
Noma	Cancrum Oris Gangrenous Stomatitis Oro-Facial Gangrene Noma Neonatorum Oral Gangrene Oro-Facial Noma Stomatitis Gangrenosa Stomatonecrosis Gangrene Stomatitis
Bladder Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Bladder Epidermoid Carcinoma Of The Urinary Bladder Carcinoma Squamous Cell Bladder
Afferent Loop Syndrome	Afferent Limb Syndrome
Shipyard Eye	Epidemic Keratoconjunctivitis Ekc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09423	NOMO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NOMO2	MGD	MGI:2385850