Ctns - cystinosin, lysosomal cystine transporter Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 287478

Summary

Predicted to enable L-cystine transmembrane transporter activity and solute:proton symporter activity. Involved in L-cystine transport; negative regulation of hydrogen peroxide biosynthetic process; and positive regulation of mitochondrial membrane potential. Predicted to be located in several cellular components, including cytoplasmic vesicle; intermediate filament cytoskeleton; and lysosome. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in cystinosis. Orthologous to human CTNS (cystinosin, lysosomal cystine transporter). [provided by Alliance of Genome Resources, Apr 2022]

Ctns Products (1)

mRNA	Protein	Name
NM_001191647.1	NP_001178576.1	cystinosin precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in L-cystine transport	IMP IMP: Inferred from mutant phenotype	26482480	RGD
involved in brush border assembly	IMP IMP: Inferred from mutant phenotype	35695380	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	35695380	RGD
involved in negative regulation of hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	26482480	RGD
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	26482480	RGD
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	26482480	RGD
involved in positive regulation of thyroid hormone generation	IMP IMP: Inferred from mutant phenotype	35695380	RGD
involved in proximal tubule morphogenesis	IMP IMP: Inferred from mutant phenotype	35695380	RGD
involved in renal D-glucose absorption	IMP IMP: Inferred from mutant phenotype	35695380	RGD
involved in renal albumin absorption	IMP IMP: Inferred from mutant phenotype	35695380	RGD
involved in renal phosphate ion absorption	IMP IMP: Inferred from mutant phenotype	35695380	RGD
involved in renal water absorption	IMP IMP: Inferred from mutant phenotype	35695380	RGD
involved in thyroid gland development	IMP IMP: Inferred from mutant phenotype	35695380	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cystinosin	cystinosis, nephropathic

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03313	CTNS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctns	NCBI	NCBI:1497