NDUFS2 - Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 289218

Summary

Enables oxygen sensor activity. Contributes to NADH dehydrogenase (ubiquinone) activity. Involved in cellular response to oxygen levels and mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Apr 2022]

NDUFS2 Products (1)

mRNA Protein Name
NM_001011907.1 NP_001011907.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to NADH dehydrogenase (ubiquinone) activity IMP
IMP: Inferred from mutant phenotype
30922174 RGD
enables oxygen sensor activity IMP
IMP: Inferred from mutant phenotype
30922174 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxygen levels IMP
IMP: Inferred from mutant phenotype
30922174 RGD
involved in mitochondrial electron transport, NADH to ubiquinone IMP
IMP: Inferred from mutant phenotype
30922174 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
30922174 RGD
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
30922174 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

  • CI-49kD

  • NADH dehydrogenase (ubiquinone) Fe-S protein 2

  • NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like

  • NADH-ubiquinone oxidoreductase 49 kDa subunit

  • complex I-49kD

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09158 NDUFS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21898 Ndufs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NDUFS2 NCBI NCBI:4720