NDUFS2 - Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 Gene

Rattus norvegicus

Gene ID: 289218 | Gene type: protein coding

About NDUFS2

Summary

Enables oxygen sensor activity. Contributes to NADH dehydrogenase (ubiquinone) activity. Involved in cellular response to oxygen levels and mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Apr 2022]

NDUFS2 Products(1)

mRNA	Protein	Name
NM_001011907.1	NP_001011907.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to NADH dehydrogenase (ubiquinone) activity	IMP IMP: Inferred from mutant phenotype	30922174	RGD
enables oxygen sensor activity	IMP IMP: Inferred from mutant phenotype	30922174	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxygen levels	IMP IMP: Inferred from mutant phenotype	30922174	RGD
involved in mitochondrial electron transport, NADH to ubiquinone	IMP IMP: Inferred from mutant phenotype	30922174	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	30922174	RGD
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	30922174	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

CI-49kD	NADH dehydrogenase (ubiquinone) Fe-S protein 2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like	NADH-ubiquinone oxidoreductase 49 kDa subunit
complex I-49kD

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09158	NDUFS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21898	Ndufs2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	NDUFS2	NCBI	NCBI:4720

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