Capn3 - calpain 3 Gene

Also Known as p94; Lp82; Lp84; Lp85

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29155

Summary

Enables several functions, including calcium-dependent cysteine-type endopeptidase activity; enzyme binding activity; and titin binding activity. Involved in several processes, including response to calcium ion; response to muscle activity; and sodium-dependent self proteolysis. Located in T-tubule; Z disc; and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Orthologous to human CAPN3 (calpain 3). [provided by Alliance of Genome Resources, Apr 2022]

Capn3 Products (1)

mRNA Protein Name
NM_017117.2 NP_058813.2 calpain-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
11904300 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
18676612 RGD
enables peptidase activity IDA
IDA: Inferred from direct assay
14506720 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16938483 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
18676612 RGD
enables titin binding IDA
IDA: Inferred from direct assay
19144634 RGD
Biological Process GO Annotation Evidence References Source
involved in proteolysis IDA
IDA: Inferred from direct assay
18676612 RGD
involved in response to calcium ion IDA
IDA: Inferred from direct assay
11904300 RGD
involved in response to muscle activity IDA
IDA: Inferred from direct assay
19144634 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15726428 RGD
involved in self proteolysis IDA
IDA: Inferred from direct assay
18676612 RGD
involved in sodium-dependent self proteolysis IDA
IDA: Inferred from direct assay
20460380 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
19144634 RGD
located in Z disc IDA
IDA: Inferred from direct assay
19144634 RGD
located in myofibril IDA
IDA: Inferred from direct assay
19144634 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
19144634 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calpain-3

  • CANP 3

  • calcium-activated neutral proteinase 3

  • calpain L3

  • calpain p94

  • muscle-specific calcium-activated neutral protease 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01890 CAPN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Capn3 NCBI NCBI:825