Atp8b1 - ATPase phospholipid transporting 8B1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 291555

Summary

Enables phosphatidylserine flippase activity. Predicted to be involved in several processes, including apical protein localization; lipid transport; and nervous system development. Predicted to act upstream of or within bile acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1). [provided by Alliance of Genome Resources, Apr 2022]

Atp8b1 Products (1)

mRNA Protein Name
NM_001106140.1 NP_001099610.1 phospholipid-transporting ATPase IC

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylserine flippase activity IMP
IMP: Inferred from mutant phenotype
19027009 RGD
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
11584374 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipid-transporting ATPase IC

  • ATPase, Class I, type 8B, member 1

  • ATPase, aminophospholipid transporter, class I, type 8B, member 1

  • P4-ATPase flippase complex alpha subunit ATP8B1

  • probable phospholipid-transporting ATPase IC

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01239 ATP8B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp8b1 NCBI NCBI:5205