Atp8b1 - ATPase phospholipid transporting 8B1 Gene

Rattus norvegicus

Gene ID: 291555 | Gene type: protein coding

About Atp8b1

Summary

Enables phosphatidylserine flippase activity. Predicted to be involved in several processes, including apical protein localization; lipid transport; and nervous system development. Predicted to act upstream of or within bile acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1). [provided by Alliance of Genome Resources, Apr 2022]

Atp8b1 Products(1)

mRNA	Protein	Name
NM_001106140.1	NP_001099610.1	phospholipid-transporting ATPase IC

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylserine flippase activity	IMP IMP: Inferred from mutant phenotype	19027009	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in brush border membrane	IDA IDA: Inferred from direct assay	11584374	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipid-transporting ATPase IC

ATPase, Class I, type 8B, member 1	ATPase, aminophospholipid transporter, class I, type 8B, member 1
P4-ATPase flippase complex alpha subunit ATP8B1	probable phospholipid-transporting ATPase IC

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01239	ATP8B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp8b1	NCBI	NCBI:5205

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