Vtn - vitronectin Gene

Also Known as Vn; Aa1018

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29169

Summary

Enables Collagen binding activity; heparin binding activity; and identical protein binding activity. Involved in liver regeneration and protein polymerization. Located in several cellular components, including Golgi lumen; basement membrane; and rough endoplasmic reticulum lumen. Used to study proteinuria. Biomarker of diabetic retinopathy and visual epilepsy. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (Vitronectin). [provided by Alliance of Genome Resources, Apr 2022]

Vtn Products (1)

mRNA Protein Name
NM_019156.2 NP_062029.2 vitronectin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables collagen binding IDA
IDA: Inferred from direct assay
10988248 RGD
enables heparin binding IDA
IDA: Inferred from direct assay
8804356 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
17369286 RGD
Biological Process GO Annotation Evidence References Source
involved in liver regeneration IDA
IDA: Inferred from direct assay
10988248 RGD
involved in protein polymerization IDA
IDA: Inferred from direct assay
17369286 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi lumen IDA
IDA: Inferred from direct assay
10192552 RGD
located in basement membrane IDA
IDA: Inferred from direct assay
11728964 RGD
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
2426279 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17567740 RGD
located in rough endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
10192552 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vitronectin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15724 VTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17681 Vtn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24142 Vtn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vtn NCBI NCBI:7448
Mus musculus Vtn NCBI NCBI:22370