Aqp8 - aquaporin 8 Gene

Rattus norvegicus

Also known as AQP-8

Gene ID: 29172 | Gene type: protein coding

About Aqp8

Summary

Enables water channel activity. Involved in canalicular bile acid transport and water transport. Located in intracellular canaliculus and intracellular membrane-bounded organelle. Biomarker of brain ischemia. Orthologous to human AQP8 (Aquaporin 8). [provided by Alliance of Genome Resources, Apr 2022]

Aqp8 Products(1)

mRNA	Protein	Name
NM_019158.2	NP_062031.1	aquaporin-8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ammonium channel activity	IDA IDA: Inferred from direct assay	15988592	RGD
enables methylammonium channel activity	IDA IDA: Inferred from direct assay	15948717	RGD
enables water channel activity	IDA IDA: Inferred from direct assay	11932260	RGD
enables water channel activity	IMP IMP: Inferred from mutant phenotype	16624991	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ammonium import across plasma membrane	IDA IDA: Inferred from direct assay	16624991	RGD
involved in ammonium transmembrane transport	IDA IDA: Inferred from direct assay	15988592	RGD
involved in canalicular bile acid transport	IDA IDA: Inferred from direct assay	11932260	RGD
involved in hydrogen peroxide transmembrane transport	IMP IMP: Inferred from mutant phenotype	31372390	RGD
involved in methylammonium transmembrane transport	IMP IMP: Inferred from mutant phenotype	23299935	RGD
involved in methylammonium transport	IDA IDA: Inferred from direct assay	15948717	RGD
involved in transepithelial water transport	IDA IDA: Inferred from direct assay	16177191	RGD
involved in water transport	IDA IDA: Inferred from direct assay	11932260	RGD
involved in water transport	IMP IMP: Inferred from mutant phenotype	16624991	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11436986	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11205061	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	18059526	RGD
located in intracellular canaliculus	IDA IDA: Inferred from direct assay	11436986	RGD
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	15749715	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	33892285	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	33892285	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aquaporin-8

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00880	AQP8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aqp8	NCBI	NCBI:343

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