Shtn1 - shootin 1 Gene

Also Known as Shootin1; RGD1311558

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 292139

Summary

Enables actin filament binding activity and cell adhesion molecule binding activity. Involved in several processes, including Cdc42 protein signal transduction; actin filament bundle retrograde transport; and netrin-activated signaling pathway. Acts upstream of or within axonogenesis. Located in axonal growth cone; filopodium; and lamellipodium. Orthologous to human SHTN1 (shootin 1). [provided by Alliance of Genome Resources, Apr 2022]

Shtn1 Products (2)

mRNA Protein Name
NM_001079705.4 NP_001073173.2 shootin-1 isoform 1
NM_001303537.1 NP_001290466.1 shootin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
23453953 RGD
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
18519736 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17030985 RGD
Biological Process GO Annotation Evidence References Source
involved in Cdc42 protein signal transduction IDA
IDA: Inferred from direct assay
23453953 RGD
involved in Ras protein signal transduction IDA
IDA: Inferred from direct assay
23453953 RGD
involved in actin filament bundle retrograde transport IMP
IMP: Inferred from mutant phenotype
23453953 RGD
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
17030985 RGD
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
17439943 RGD
involved in cytoplasmic actin-based contraction involved in cell motility IDA
IDA: Inferred from direct assay
23453953 RGD
involved in netrin-activated signaling pathway IDA
IDA: Inferred from direct assay
23453953 RGD
involved in positive regulation of axon extension IDA
IDA: Inferred from direct assay
18519736 RGD
involved in substrate-dependent cell migration, cell extension IDA
IDA: Inferred from direct assay
23453953 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
18519736 RGD
located in filopodium IDA
IDA: Inferred from direct assay
18519736 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
18519736 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

shootin-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12888 SHTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shtn1 NCBI NCBI:57698