Dync1h1 - dynein cytoplasmic 1 heavy chain 1 Gene

Rattus norvegicus

Also known as DHC1a; Dnch1; Dnchc1

Gene ID: 29489 | Gene type: protein coding

About Dync1h1

Summary

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in cellular response to 3,3',5-triiodo-L-thyronine; cellular response to nerve growth factor stimulus; and spermatid development. Located in several cellular components, including manchette; neuronal cell body; and nuclear envelope. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant non-syndromic intellectual disability 13; and spinal muscular atrophy with lower extremity predominance 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Dync1h1 Products(1)

mRNA	Protein	Name
NM_019226.3	NP_062099.3	cytoplasmic dynein 1 heavy chain 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14985359	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to 3,3',5-triiodo-L-thyronine	IEP IEP: Inferred from expression pattern	8922673	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	8922673	RGD
involved in spermatid development	IEP IEP: Inferred from expression pattern	8006076	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	1387878	RGD
located in manchette	IDA IDA: Inferred from direct assay	8006076	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	1387878	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	8006076	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoplasmic dynein 1 heavy chain 1

MAP 1C	cytoplasmic dynein heavy chain 1
dynein heavy chain, cytosolic	dynein, cytoplasmic, heavy chain 1
microtubule-associated protein 1 C

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04082	DYNC1H1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dync1h1	NCBI	NCBI:1778

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