Dync1h1 - dynein cytoplasmic 1 heavy chain 1 Gene

Also Known as DHC1a; Dnch1; Dnchc1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29489

Summary

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in cellular response to 3,3',5-triiodo-L-thyronine; cellular response to nerve growth factor stimulus; and spermatid development. Located in several cellular components, including manchette; neuronal cell body; and nuclear envelope. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant non-syndromic intellectual disability 13; and spinal muscular atrophy with lower extremity predominance 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Dync1h1 Products (1)

mRNA Protein Name
NM_019226.3 NP_062099.3 cytoplasmic dynein 1 heavy chain 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14985359 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to 3,3',5-triiodo-L-thyronine IEP
IEP: Inferred from expression pattern
8922673 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
8922673 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
8006076 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
1387878 RGD
located in manchette IDA
IDA: Inferred from direct assay
8006076 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
1387878 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
8006076 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic dynein 1 heavy chain 1

  • MAP 1C

  • cytoplasmic dynein heavy chain 1

  • dynein heavy chain, cytosolic

  • dynein, cytoplasmic, heavy chain 1

  • microtubule-associated protein 1 C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04082 DYNC1H1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dync1h1 NCBI NCBI:1778