2. Gene
  3. Pitx3 - paired-like homeodomain 3 Gene

Pitx3 - paired-like homeodomain 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 29609 | Gene type: protein coding

About Pitx3

Summary

Enables DNA-binding transcription factor activity. Involved in several processes, including cellular response to glial cell derived neurotrophic factor; positive regulation of cell proliferation in midbrain; and response to alkaloid. Located in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3). [provided by Alliance of Genome Resources, Apr 2022]

Pitx3 Products(1)

mRNA Protein Name
NM_019247.2 NP_062120.1 pituitary homeobox 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10800925 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glial cell derived neurotrophic factor IEP
IEP: Inferred from expression pattern
21865882 RGD
involved in negative regulation of gliogenesis IDA
IDA: Inferred from direct assay
18385323 RGD
involved in negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
18385323 RGD
involved in positive regulation of cell proliferation in midbrain IDA
IDA: Inferred from direct assay
18385323 RGD
involved in positive regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
18385323 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
17070804 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
18951485 RGD
involved in response to methamphetamine hydrochloride IEP
IEP: Inferred from expression pattern
21547080 RGD
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
28743636 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pituitary homeobox 3

homeobox protein PITX3

homeobox protein PTX3

paired-like homeodomain transcription factor 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10583 PITX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pitx3 NCBI NCBI:5309