Pcbd1 - pterin-4 alpha-carbinolamine dehydratase 1 Gene

Also Known as Pcd; Phs; DCoH; Pcbd; TCF1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29700

Summary

This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. [provided by RefSeq, Jan 2014]

Pcbd1 Products (1)

mRNA Protein Name
NM_001007601.2 NP_001007602.1 pterin-4-alpha-carbinolamine dehydratase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IDA
IDA: Inferred from direct assay
1465414 RGD
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
1763325 RGD
Biological Process GO Annotation Evidence References Source
involved in L-phenylalanine metabolic process IDA
IDA: Inferred from direct assay
1465414 RGD
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
1763325 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pterin-4-alpha-carbinolamine dehydratase

  • 4-alpha-hydroxy-tetrahydropterin dehydratase

  • 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)

  • dimerization cofactor of HNF1

  • phenylalanine hydroxylase-stimulating protein

  • pterin carbinolamine dehydr

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10113 PCBD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcbd1 NCBI NCBI:5092