Gabrg2 - gamma-aminobutyric acid type A receptor subunit gamma 2 Gene

Rattus norvegicus

Gene ID: 29709 | Gene type: protein coding

About Gabrg2

Summary

Enables GABA-A receptor activity and Chloride Channel activity. Contributes to GABA Receptor activity. Involved in GABAergic synaptic transmission. Located in cytoplasm; dendrite membrane; and inhibitory synapse. Part of GABA Receptor complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in childhood absence epilepsy; developmental and epileptic encephalopathy 74; and familial febrile seizures 8. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2). [provided by Alliance of Genome Resources, Apr 2022]

Gabrg2 Products(2)

mRNA	Protein	Name
NM_001393775.1	NP_001380704.1	gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor
NM_183327.2	NP_899156.1	gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to GABA receptor activity	IDA IDA: Inferred from direct assay	12930820	RGD
enables GABA-A receptor activity	IDA IDA: Inferred from direct assay	2561970	RGD
enables chloride channel activity	IDA IDA: Inferred from direct assay	2561970	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12091434	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to zinc ion	IDA IDA: Inferred from direct assay	20371809	RGD
involved in chloride transport	IDA IDA: Inferred from direct assay	2561970	RGD
involved in response to anesthetic	IMP IMP: Inferred from mutant phenotype	16037152	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	11410716	RGD
involved in synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	12930820	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of GABA receptor complex	IDA IDA: Inferred from direct assay	12930820	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	9014159	RGD
located in cell surface	IDA IDA: Inferred from direct assay	17989301	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	15620359	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9464994	RGD
located in inhibitory synapse	IDA IDA: Inferred from direct assay	20417281	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	9464994	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	9014159	RGD
located in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	9464994	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit gamma-2

GABA(A) receptor subunit gamma-2	gamma-aminobutyric acid (GABA) A receptor, gamma 2
gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2	gamma-aminobutyric acid A receptor, gamma 2
gamma-aminobutyric acid type A receptor gamma 2 subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05221	GABRG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabrg2	NCBI	NCBI:2566

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